Three-dimensional modeling of a portable medical device for magnetic separation of particles from biological fluids
Three-dimensional modeling of a portable medical device for magnetic separation of particles from biological fluids
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DOI：
10.1088/0031-9155/52/17/007
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发表时间：
2007-09-07
影响因子：
3.5
通讯作者：
Rosengart, Axel J.
中科院分区：
文献类型：
--
作者：
Chen, Haitao;Bockenfeld, Danny;Rosengart, Axel J.
已经开发出一种便携式分离器，可以在潜在的高流量状态下定量分离血液中的磁球，以达到人体解毒的目的。在分离器设计中，一系列生物相容性毛细管和可磁化线浸入由两个永磁体产生的外部磁场中。这些线被磁化并且来自磁化线的高磁场梯度有助于从血流中收集血源性磁性纳米/微球。在本研究中，创建了 3D 数值模型，并使用 COMSOL Multiphysics 3.3 (R) 分析了管线配置对系统捕获效率的影响。结果表明，相对于四种起始配置，以双向交替线和管为特征的配置是最佳设计。初步体外实验验证了数值预测。研究结果帮助我们优化了便携式磁力分离器原型，该分离器适用于从人体血流中快速隔离磁性纳米/微球，同时适应必要的临床边界条件。
A portable separator has been developed to quantitatively separate blood-borne magnetic spheres in potentially high-flow regimes for the human detoxification purpose. In the separator design, an array of biocompatible capillary tubing and magnetizable wires is immersed in an external magnetic field that is generated by two permanent magnets. The wires are magnetized and the high magnetic field gradient from the magnetized wires helps to collect blood-borne magnetic nano/micro-spheres from the blood flow. In this study, a 3D numerical model was created and the effect of tubing-wire configurations on the capture efficiency of the system was analyzed using COMSOL Multiphysics 3.3 (R). The results showed that the configuration characterized by bi-directionally alternating wires and tubes was the best design with respect to the four starting configurations. Preliminary in vitro experiments verified the numerical predictions. The results helped us to optimize a prototype portable magnetic separator that is suitable for rapid sequestration of magnetic nano/ microspheres from the human blood stream while accommodating necessary clinical boundary conditions.