Acute Nicotine Alteration of Sensory Memory Impairment in Smokers With Schizophrenia
Acute Nicotine Alteration of Sensory Memory Impairment in Smokers With Schizophrenia
复制标题
DOI：
10.1097/jcp.0b013e3181f0c9c6
复制
发表时间：
2010-10-01
影响因子：
2.9
通讯作者：
Knott, Verner J.
中科院分区：
文献类型：
--
作者：
Dulude, Louise;Labelle, Alain;Knott, Verner J.
内容：精神分裂症患者有很高的吸烟率，并且在感觉处理方面也表现出严重的缺陷，这可能部分地通过吸烟吸入尼古丁的急性作用得到改善。错配负波（MMN），听觉感觉记忆的前注意事件相关电位指数，在精神分裂症中减少。MMN是增加健康对照与急性nitricotin.Objective：利用MMN比较听觉感觉记忆在最低限度的烟草剥夺（3小时）患者和匹配的烟草剥夺吸烟对照，并评估急性尼古丁对MMN索引的感觉记忆处理的患者。设计：事件相关电位记录在2个听觉oddball范式，一个涉及音调频率的变化（频率MMN）和一个涉及音调持续时间的变化（持续时间MMN）。对照组在非治疗条件下评估一次，患者在随机双盲治疗条件下评估两次，包括安慰剂和尼古丁（8 mg）口香糖。设置：门诊精神卫生中心。患者：12名精神分裂症吸烟者和12名对照组吸烟者。与对照组相比，患者组MMN的频率振幅和持续时间振幅均降低（P < 0.001和P < 0.04）。除了延长持续时间MMN的峰潜伏期外，与安慰剂组相比，尼古丁组患者MMN持续时间的振幅增加（P < 0.01）（P G 0.01），但不是他们的频率MMN，与对照组中看到的水平相当。这些初步研究结果首次证明，急性尼古丁可以使患有神经功能缺损的患者感觉记忆处理的时间方面正常化。精神分裂症，这是一种可能由α 7烟碱乙酰胆碱受体激活介导的效应，其功能在精神分裂症中减弱。尼古丁的这些改善作用可能对理解吸烟与精神分裂症之间的密切关系以及开发尼古丁药物疗法以减轻精神分裂症的感觉记忆障碍具有意义。
Context: Patients with schizophrenia have a high rate of cigarette smoking and also exhibit profound deficits in sensory processing, which may in part be ameliorated by the acute actions of smoke-inhaled nicotine. The mismatch negativity (MMN), a preattentive event-related potential index of auditory sensory memory, is diminished in schizophrenia. The MMN is increased in healthy controls with acute nicotine.Objective: To utilize the MMN to compare auditory sensory memory in minimally tobacco-deprived (3 hours) patients and matched tobacco-deprived smoking controls and to assess the effects of acute nicotine on MMN-indexed sensory memory processing in the patients.Design: Event-related potentials were recorded in 2 auditory oddball paradigms, one involving tone frequency changes (frequency MMN) and one involving tone duration changes (duration MMN). Controls were assessed once under nontreatment conditions, and patients were assessed twice under randomized double-blind treatment conditions involving placebo and nicotine (8 mg) gum.Setting: Outpatient mental health center.Patients: Twelve smokers with schizophrenia and twelve control smokers.Results: Compared with the controls, the patients showed reduced frequency-MMN (P < 0.001) and duration-MMN (P < 0.04) amplitudes. In addition to prolonging peak latency in duration MMN (P < 0.01), nicotine, relative to placebo, increased the amplitude of the patients' duration MMN (P G 0.01), but not their frequency MMN, to a level comparable with that seen in the controls.Conclusions: These preliminary findings demonstrate for the first time that acute nicotine can normalize temporal aspects of sensory memory processing in patients with schizophrenia, an effect that may be mediated by activation of alpha 7 nicotinic acetylcholine receptors, the function of which is diminished in schizophrenia. These ameliorating actions of nicotine may have implications for understanding the close relationship between tobacco smoking and schizophrenia and for developing nicotinic pharmacotherapies to alleviate sensory memory impairments in schizophrenia.