VARIATIONS IN MORTALITY BY WEIGHT AMONG 750,000 MEN AND WOMEN
VARIATIONS IN MORTALITY BY WEIGHT AMONG 750,000 MEN AND WOMEN
复制标题
DOI：
10.1016/0021-9681(79)90119-x
复制
发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
GARFINKEL, L
中科院分区：
文献类型：
--
作者：
LEW, EA;GARFINKEL, L
这篇论文的基础是美国癌症协会在1959-1972年间进行的一项长期前瞻性研究的一部分。描述了从普通人群中抽取的750,000名男性和女性根据体重变化而产生的死亡率。死亡率在接近平均体重和低于平均体重10%-20%的人群中最低。体重比平均体重高30-40%的男性和女性的死亡率比平均体重的高近50%；比平均体重高40%以上的男性和女性的死亡率比平均体重的高近90%。冠心病是超重死亡率较高的主要因素，在超重30%-40%的人中，冠心病的死亡率比平均水平高55%，在超重40%以上的人中，冠心病的死亡率高出约100%。癌症死亡率仅在超重40%或以上的人群中升高；结肠癌和直肠癌是男性癌症死亡率过高的主要部位，而胆囊癌和胆道癌、乳腺癌、子宫颈、子宫内膜、子宫和卵巢癌是女性死亡率过高的主要部位。糖尿病死亡率在超重人群中尤其高，尤其是女性。这项研究的死亡率结果与1959年基于450万投保人经验的BUILD和血压研究结果非常接近。
A portion of a long-term prospective study conducted by the American Cancer Society during 1959-1972 was the basis of this paper. The mortality experience according to variations in wt among 750,000 men and women drawn from the general population was described. The lowest mortality was found among those close to average wt and those 10-20% below average wt. Mortality among men and women 30-40% heavier than average was nearly 50% higher than among those of average wt; among those more than 40% heavier than average it was nearly 90% higher than among those of average weight. Coronary heart disease was the major factor in the higher mortality of overweights, being 55% higher among those 30-40% heavier than average, and about 100% higher among those more than 40% overweight. Cancer mortality was elevated only among those 40% or more overweight; cancer of the colon and rectum was the principal site of excess cancer mortality among men, while cancer of the gall bladder and biliary passages, breast, cervix, endometrium, uterus and ovary were the major sites of excess mortality among women. Mortality from diabetes was particularly high among overweights, especially women. The mortality findings of this study match closely those of the Build and Blood Pressure Study 1959 based on the experience of 4 1/2 million insured persons.