Synthesis of Gem-Difluorinated Fused Quinolines via Visible Light-Mediated Cascade Radical Cyclization.
Synthesis of Gem-Difluorinated Fused Quinolines via Visible Light-Mediated Cascade Radical Cyclization.
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DOI：
10.1021/acs.orglett.6b00119
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发表时间：
2016-02
期刊：
影响因子：
5.2
通讯作者：
Tiebo Xiao;Linyong Li;Yang Xie;Z. Mao;Lei Zhou
中科院分区：
文献类型：
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作者：
Tiebo Xiao;Linyong Li;Yang Xie;Z. Mao;Lei Zhou
以二氟甲基氯和烯烃为原料，通过可见光催化级联自由基环化反应合成了偕二氟稠合喹啉。在非常温和的反应条件下，以中等至良好的产率组装了各种高度官能化的稠合喹啉。该反应通过简单的衍生化扩展了氯二氟乙酸作为偕二氟亚甲基化结构单元的应用，特别是在合成偕二氟稠合杂环方面，这是现有方法难以获得的。
A facile synthesis of gem-difluorinated fused quinolines via visible light-mediated cascade radical cyclization between functionalized difluoromethyl chlorides and alkenes was developed. Various highly functionalized fused quinolines were assembled in moderate to good yields under very mild reaction conditions. The reaction extends the applications of chlorodifluoroacetic acid as the gem-difluoromethylenated building block by simple derivatization, especially in the synthesis of gem-difluorinated fused heterocyclic rings, which are difficult to access with existing methods.