Embryonic stem cell-derived glial precursors:: A source of myelinating transplants
Embryonic stem cell-derived glial precursors:: A source of myelinating transplants
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DOI：
10.1126/science.285.5428.754
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发表时间：
1999-07-30
期刊：
影响因子：
56.9
通讯作者：
McKay, RDG
中科院分区：
文献类型：
--
作者：
Brüstle, O;Jones, KN;McKay, RDG
自我更新、全能的胚胎干细胞（ES）可以为移植提供几乎无限的供体来源。设计了一种允许从ES细胞体外生成少突胶质细胞和星形胶质细胞前体的方案。在人类髓鞘疾病的大鼠模型中的移植表明，这些ES细胞衍生的前体与宿主神经元相互作用，并有效地使脑和脊髓中的轴突髓鞘化。因此，ES细胞可以作为神经移植的细胞类型特异性体细胞前体的有价值的来源。
Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.