Mineral-Coated Polymer Microspheres for Controlled Protein Binding and Release
Mineral-Coated Polymer Microspheres for Controlled Protein Binding and Release
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DOI：
10.1002/adma.200801808
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发表时间：
2009-05-18
影响因子：
29.4
通讯作者：
Murphy, William L.
中科院分区：
文献类型：
--
作者：
Jongpoiboonkit, Leenaporn;Franklin-Ford, Travelle;Murphy, William L.
通过仿生过程产生具有骨样矿物涂层的聚合物微球，并且这种可生物降解的涂层用作递送生物分子的载体。酸性和碱性蛋白质可控地结合并从这些微球释放，表明这种方法可用于结合和递送广泛的生物活性分子。
Polymer microspheres with a bonelike mineral coating are generated via a biomimetic process, and this biodegradable coating is used as a carrier for delivery of biological molecules. Acidic and basic proteins are controllably bound and released from these microspheres, suggesting that this approach can be used for binding and delivery of a broad range of biologically active molecules.