ARP3 promotes tumor metastasis and predicts a poor prognosis in hepatocellular carcinoma
ARP3 promotes tumor metastasis and predicts a poor prognosis in hepatocellular carcinoma
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ARP3促进肿瘤转移并预测肝细胞癌的不良预后
DOI：
10.1016/j.prp.2018.05.028
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发表时间：
2018-09-01
影响因子：
2.8
通讯作者：
Lu, Cuihua
中科院分区：
文献类型：
--
作者：
Lv, Jiale;Liu, Jinxia;Lu, Cuihua
肝细胞癌（HCC）是全球癌症相关死亡的第二大原因。因此，研究肝癌发生的精确分子机制具有深远的意义。在本研究中，我们发现ARP3在HCC组织和细胞系中的表达明显上调。肝癌标本研究表明，ARP3的表达与HCC的病理分级、远处转移及血管浸润密切相关。多因素分析结果显示，ARP3是HCC患者独立的预后因素。在体外实验中，敲低ARP3表达可显著抑制HCC细胞的侵袭和迁移，改变EMT标志物的表达。基于以上结论，我们认为ARP3可能是HCC患者潜在的预后指标和治疗靶点。
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Therefore, the study of the precise molecular mechanism underlying hepatocarcinogenesis has profound significance. In this study, we found that the expression of ARP3 was significantly up-regulated in HCC tissues and cell lines. Studies in liver cancer specimens showed that the expression of ARP3 is closely related to the pathological grade, distant metastasis and vascular invasion of HCC. According to the results of multivariate analysis, ARP3 is an independent prognostic factor for HCC patients. In vitro, knockdown of ARP3 expression significantly inhibited the invasion and migration of HCC cells and altered the expression of EMT markers. Based on the above conclusions, we conclude that ARP3 may be a potential prognostic indicator and therapeutic target for HCC patients.