Neurovascular crosstalk between interneurons and capillaries is required for vision
Neurovascular crosstalk between interneurons and capillaries is required for vision
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DOI：
10.1172/jci80297
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发表时间：
2015-06-01
影响因子：
15.9
通讯作者：
Friedlander, Martin
中科院分区：
文献类型：
--
作者：
Usui, Voshihiko;Westenskow, Peter D.;Friedlander, Martin
神经血管单元内神经元、血管系统和神经胶质之间的功能相互作用对于维持视网膜和其他CNS组织至关重要。例如，感觉神经视网膜的结构是具有神经元和血管的交替层的高度组织化的结构，其匹配神经元活动的代谢需求与灌注血液内的适当氧气供应。在这里，使用小鼠遗传模型和细胞消融策略，我们已经证明，视网膜中间神经元的一个子集，无长突和水平细胞，形成神经血管单位与毛细血管在2的3视网膜血管丛。此外，我们确定这些细胞是通过精确调节缺氧诱导因子和促血管生成因子来产生和维持视网膜内血管所需的，并且无长突和水平细胞功能障碍诱导视网膜内血管和实质性视觉缺陷的改变。这些研究结果表明，特定的视网膜中间神经元和视网膜内血管是高度相互依赖的，并且其中一个或两个的丧失对光感受器的存活和功能产生深远的影响。
Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. For example, the architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. Here, using murine genetic models and cell ablation strategies, we have demonstrated that a subset of retinal interneurons, the amacrine and horizontal cells, form neurovascular units with capillaries in 2 of the 3 retinal vascular plexuses. Moreover, we determined that these cells are required for generating and maintaining the intraretinal vasculature through precise regulation of hypoxia-inducible and proangiogenic factors, and that amacrine and horizontal cell dysfunction induces alterations to the intraretinal vasculature and substantial visual deficits. These findings demonstrate that specific retinal interneurons and the intraretinal vasculature are highly interdependent, and loss of either or both elicits profound effects on photoreceptor survival and function.