Effect of citric acid addition on disaggregation of crystalline hydroxyapatite nanoparticles under calcium-rich conditions
Effect of citric acid addition on disaggregation of crystalline hydroxyapatite nanoparticles under calcium-rich conditions
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DOI：
10.1016/j.matlet.2015.04.125
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发表时间：
2015-10
影响因子：
3
通讯作者：
Masaki Kakiage;K. Iwase;Hidehiko Kobayashi
中科院分区：
文献类型：
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作者：
Masaki Kakiage;K. Iwase;Hidehiko Kobayashi
研究了柠檬酸（CA）对富钙条件下羟基磷灰石（HAp）纳米颗粒结晶分解的影响。在富钙条件下，采用湿法化学沉淀法制备HAp纳米粒子，与化学测量的HAp的Ca/P摩尔比相比，在添加Ca的情况下，其中含有过量的钙离子。富钙条件下柠檬酸钙的形成对抑制纳米级HAp初级颗粒的聚集非常有效，从而获得了高度结晶和分解的HAp纳米粒子。
The effect of citric acid (CA) addition on the disaggregation of crystalline hydroxyapatite (HAp) nanoparticles under calcium-rich conditions was investigated in this study. HAp nanoparticles were prepared by a wet chemical precipitation process under calcium-rich conditions, which included an excess amount of calcium ions compared with the stoichiometric Ca/P molar ratio of HAp, with added CA. The formation of calcium citrate under calcium-rich conditions was highly effective for inhibiting the aggregation of nanosize HAp primary particles, and thus highly crystalline and disaggregated HAp nanoparticles were obtained.