Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin
Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin
复制标题
核小体启发的纳米载体通过使用富勒醇与阿霉素组装来提高封装效率并减少化疗副作用
DOI：
10.1016/j.biomaterials.2018.03.015
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发表时间：
2018-06-01
期刊：
影响因子：
14
通讯作者：
Chen, Chunying
中科院分区：
文献类型：
--
作者：
Tang, Jinglong;Zhang, Ruirui;Chen, Chunying
化疗药物已被广泛用于治疗癌症，然而，化疗通常会导致严重的副作用和失败。已经探索了各种纳米材料和策略用于药物递送以提高化学药物的功效。将化学药物装载到纳米递送系统上的一个关键是增强包封效率，特别是对于装载有亲水性药物的聚合物纳米颗粒。受真核生物将数百万个基因包装在细胞核中的能力的启发，我们开发了一种类似核的混合纳米颗粒，以实现对阿霉素（Dox）的超高包封，同时减少副作用。我们利用富勒烯醇作为“组蛋白”，包装大量的Dox，并使用PEG-PLGA作为“核膜”包裹“核小体”（富勒烯醇和Dox复合物）以稳定复合物。值得注意的是，聚合物胶束中Dox的包封效率从接近5%增加到接近79%。更重要的是，仿生启发的传递系统显着减少化学药物的副作用，通过利用富勒烯醇的自由基清除能力。这种新型药物递送设计方法为提高富勒醇在癌症治疗药物递送系统中的适用性提供了有用的见解。(C)2018爱思唯尔有限公司版权所有。
Chemodrugs have been widely used to treat cancer; however, the chemotherapy usually leads to serious side effects and failure. Various nanomaterials and strategies have been explored for drug delivery to improve the efficacy of chemodrugs. One key to loading chemodrugs onto a nano-delivery system is enhancement of the encapsulation efficiency, especially for polymeric nanoparticles being loaded with hydrophilic drugs. Inspired by the ability of eukaryote to package millions of genes in the nucleus wrapping and condensing DNA around histones to form chromosomes, here we developed a karyon-like hybrid nanoparticle to achieve ultra-high encapsulation of doxorubicin (Dox) with reduced side effects. We utilized fullerenol as a "histone", packaged a great number of Dox, and used PEG-PLGA as the "karyotheca" coating the "nucleosome" (fullerenol and Dox complex) to stabilize the complex. It is noteworthy that the encapsulation efficiency of Dox in the polymeric micelles was increased from similar to 5% to similar to 79%. What's more, the biomimetic-inspired delivery system significantly reduced the chemodrug side effects by utilizing the radical scavenging ability of fullerenol. This novel drug-delivery design approach provides useful insights for improving the applicability of fullerenol in drug delivery systems for cancer therapy. (C) 2018 Elsevier Ltd. All rights reserved.