Volume-Rendered Optical Coherence Tomography of Diabetic Retinopathy Pilot Study
Volume-Rendered Optical Coherence Tomography of Diabetic Retinopathy Pilot Study
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DOI：
10.1016/j.ajo.2015.09.010
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发表时间：
2015-12-01
影响因子：
4.2
通讯作者：
Spaide, Richard F.
中科院分区：
文献类型：
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作者：
Spaide, Richard F.
目得：为了探讨视网膜血管的发现和相关的解剖异常，在中央黄斑的眼睛与糖尿病视网膜病变，使用体积渲染血管造影和结构光学相干断层扫描。研究设计：观察cases series.METHODS：在这项回顾性研究中，25眼的14个连续的患者进行了成像与光学相干断层扫描（OCT）使用分裂频谱振幅去相关。将结构OCT数据分割为囊样空间，并整合到血管造影数据中，用于后续的体积绘制。可以降低各血管层的不透明度，以改善更深结构的可视化，并且图像可以绕3个轴旋转。内部和深血管丛进行了分析，如囊状空间和视网膜内层disorganisation的结构变化。结果：视网膜血管血流异常表现为大流量空洞的内部血管层与保留的大血管和汇合区的流量损失在深丛。囊样水肿区域与深血管层中的拓扑学共定位流空相关。在没有水肿的眼睛中，深丛的孤立异常与内核层的变薄有关，两层的异常均与视网膜内层的OCT结果紊乱有关。糖尿病视网膜病变中广泛的血管异常可以沿着视网膜中相应的解剖学变化，使用容积-这种成像方法提供了改善眼睛血管疾病可视化的潜力。(C)2015年，Elsevier Inc. All rights reserved.
PURPOSE: To investigate the retinal vascular findings and associated anatomic abnormalities in the central macula of eyes with diabetic retinopathy using volume-rendered angiographic and structural optical coherence tomography.STUDY DESIGN: Observational case series.METHODS: In this retrospective study 25 eyes of 14 consecutive patients were imaged with optical coherence tomography (OCT) using split-spectrum amplitude decor-relation. The structural OCT data were segmented for cystoid spaces and integrated into the angiographic data for subsequent volume rendering. The opacity of various vascular layers could be decreased to improve visualization of deeper structures and the images could be rotated about 3 axes. The inner and deep vascular plexus were analyzed in relation to structural changes such as cystoid spaces and disorganization of the retinal inner layers.RESULTS: Retinal vascular flow abnormalities manifested by large flow voids in the inner vascular layer with retention of large vessels and confluent areas of flow loss in the deep plexus. Areas of cystoid edema were associated with topographically colocalizing flow voids in the deep vascular layer. In eyes with no edema isolated abnormalities of the deep plexus were associated with thinning of the inner nuclear layer and abnormalities of both layers were associated uniformly with the OCT findings of disorganization of the retinal inner layers.CONCLUSIONS: Widespread vascular abnormalities in diabetic retinopathy could be delineated along with the corresponding anatomic changes in the retina using volume-rendered angiographic and structural OCT. This method of imaging offers potential to improve " visualization of vascular disorders of the eye. (C) 2015 by Elsevier Inc. All rights reserved.