From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle.
From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle.
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DOI：
10.1159/000353883
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发表时间：
2013
影响因子：
1.7
通讯作者：
Chalmers S
中科院分区：
文献类型：
--
作者：
McCarron JG;Wilson C;Sandison ME;Olson ML;Girkin JM;Saunter C;Chalmers S
线粒体排列的多样性，源于细胞器的静态或移动，或在动态重塑的网络中融合和分裂，才刚刚开始受到重视。虽然在了解重组线粒体的蛋白质方面取得了重大进展，但对各种排列的生理意义却知之甚少。缺乏理解的部分原因可能是线粒体形态的研究大多是在培养细胞中进行的。培养细胞的简单解剖结构为可视化线粒体行为提供了一个有吸引力的模型，但与天然细胞的复杂性形成对比，后者可能不会发生复杂的线粒体运动和形态。线粒体变化可能发生在原生细胞中（对应激和增殖的反应），但在缓慢的时间过程中，细胞功能的贡献尚不清楚。为了确定线粒体排列在细胞功能中的作用，关键的第一步是表征线粒体成分之间的相互作用。本综述描述了线粒体行为的三个方面：(1)形态学，(2)运动和(3)快速形状变化。提出的生理作用，其中各种线粒体安排的贡献和解释一些生理结论的困难也概述。
The diversity of mitochondrial arrangements, which arise from the organelle being static or moving, or fusing and dividing in a dynamically reshaping network, is only beginning to be appreciated. While significant progress has been made in understanding the proteins that reorganise mitochondria, the physiological significance of the various arrangements is poorly understood. The lack of understanding may occur partly because mitochondrial morphology is studied most often in cultured cells. The simple anatomy of cultured cells presents an attractive model for visualizing mitochondrial behaviour but contrasts with the complexity of native cells in which elaborate mitochondrial movements and morphologies may not occur. Mitochondrial changes may take place in native cells (in response to stress and proliferation), but over a slow time-course and the cellular function contributed is unclear. To determine the role mitochondrial arrangements play in cell function, a crucial first step is characterisation of the interactions among mitochondrial components. Three aspects of mitochondrial behaviour are described in this review: (1) morphology, (2) motion and (3) rapid shape changes. The proposed physiological roles to which various mitochondrial arrangements contribute and difficulties in interpreting some of the physiological conclusions are also outlined.
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影响因子：
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