Body mass index in older persons is associated with Alzheimer disease pathology
Body mass index in older persons is associated with Alzheimer disease pathology
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DOI：
10.1212/01.wnl.0000247046.90574.0f
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发表时间：
2006-12-12
期刊：
影响因子：
9.9
通讯作者：
Bennett, D. A.
中科院分区：
文献类型：
--
作者：
Buchman, A. S.;Schneider, J. A.;Bennett, D. A.
目标：我们研究了老年人的体重指数（BMI）与常见的年龄相关的神经病理学的相关程度，这些神经病理学已知会导致痴呆，包括阿尔茨海默病（AD）病理学、脑梗死和路易体病。研究方法：我们研究了298名已故天主教神职人员的脑尸检，这些神职人员参加了宗教秩序研究，这是一项纵向临床病理调查。在平均4.9年（SD = 2.7年）的随访期间，在年度临床评价中评估BMI。每个人的平均BMI，来自所有的评估，用于分析。多元回归分析被用来研究常见的死后神经病理学结果与死亡前平均BMI的关系。结果：平均死亡年龄为85.7岁（SD = 6.8岁），研究期间平均BMI为26.0（SD = 5.1）。以平均BMI作为结果，并控制年龄、性别和教育程度，进行了一系列线性回归模型。AD病理学水平与接近死亡的BMI相关（估计值= -1.15; SE = 0.42; p = 0.007）。然而，路易体病理学（估计值= -0.45; SE = 0.73; p = 0.53）和脑梗死（估计值= -0.10; SE = 0.61; p = 0.88）与平均BMI无关。在控制了痴呆、慢性疾病和体力活动后，AD病理学与BMI的相关性没有变化。结论：老年人的体重与阿尔茨海默病的病理学有关，无论是否患有痴呆症。
Objective: We examined the extent to which body mass index (BMI) in older persons is associated with common age-related neuropathologies known to contribute to dementia including Alzheimer disease (AD) pathology, cerebral infarction, and Lewy body disease. Methods: We studied brain autopsies from 298 deceased Catholic clergy participating in the Religious Orders Study, a longitudinal clinical-pathologic investigation. BMI was assessed at annual clinical evaluations during an average follow-up of 4.9 years (SD = 2.7 years). Each person's average BMI, derived from all evaluations, was used in analyses. Multiple regression analyses were used to examine the relation of common postmortem neuropathologic findings to average BMI prior to death. Results: Mean age at death was 85.7 years (SD = 6.8 years), and average BMI during the course of the study was 26.0 (SD = 5.1). A series of linear regression models was performed with average BMI as the outcome and controlling for age, sex, and education. Level of AD pathology was associated with BMI proximate to death (estimate = -1.15; SE = 0.42; p = 0.007). However, Lewy body pathology (estimate = -0.45; SE = 0.73; p = 0.53) and cerebral infarctions (estimate = -0.10; SE = 0.61; p = 0.88) were not associated with average BMI. The association of AD pathology with BMI was unchanged after controlling for dementia, chronic diseases, and physical activity. Conclusion: Body mass in old age is associated with Alzheimer disease pathology in persons with and without dementia.