Chemoconvulsant model of chronic spontaneous seizures.
Chemoconvulsant model of chronic spontaneous seizures.
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DOI：
10.1002/0471142301.ns0919s31
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发表时间：
2005-05-01
影响因子：
--
通讯作者：
Dudek, F Edward
中科院分区：
文献类型：
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作者：
Hellier, Jennifer L;Dudek, F Edward
损伤性癫痫的动物模型可能为了解获得性癫痫的机制提供线索。以前的颞叶癫痫（TLE）动物模型是由急性治疗产生的，通常具有高死亡率和/或与低比例的动物发生自发的慢性运动癫痫发作有关。在本单元中，提供了一种方案，用于诱导大鼠慢性癫痫，使用多次，低剂量，腹腔注射一种兴奋毒性药物，kainic酸。该方案在几乎所有接受治疗的大鼠（97%至少有两次观察到的自发性运动发作）中可靠地诱导TLE，死亡率相对较低(
Animal models of injury-induced epilepsy may provide insight into the mechanisms of acquired epilepsy. Previous animal models of temporal lobe epilepsy (TLE) were produced by acute treatments that often have high mortality rates and/or are associated with a low proportion of animals developing spontaneous, chronic motor seizures. In this unit, a protocol is provided for inducing chronic epilepsy in rats using multiple, low-dose, intraperitoneal injections of an excitotoxic agent, kainic acid. This protocol reliably induces TLE in nearly all treated rats (97% had at least two observed spontaneous motor seizures) with a relatively low mortality rate (