Brain connectivity at rest predicts individual differences in normative activity during movie watching.
Brain connectivity at rest predicts individual differences in normative activity during movie watching.
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DOI：
10.1016/j.neuroimage.2022.119100
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发表时间：
2022-06
期刊：
影响因子：
5.7
通讯作者：
Patel, Gaurav H.
中科院分区：
文献类型：
--
作者：
Gruskin, David C.;Patel, Gaurav H.
当接触相同的感官事件时，有些人的经历必然不如其他人那么典型。先前的研究通过表明一个人的感官体验的典型性与刺激诱发的大脑活动的典型性相关（通过受试者间相关性（ISC）来测量）来调查这一现象。 ISC 的个体差异最近被归因于局部神经处理的变异性。然而，这些差异在多大程度上反映了纯粹的区域内变异与大脑在区域之间传输信息的基线能力的变化尚未确定。在这里，我们发现个体的 ISC 程度和空间分布与其大脑休息时的功能组织密切相关。使用来自人类连接组项目的静息状态和电影观看功能磁共振成像数据，我们揭示了静息状态功能连接（RSFC）配置文件可用于预测皮层范围的 ISC。类似的区域水平分析表明，观看电影期间大脑区域表现出的 ISC 水平与其与其他区域在休息时的连接相关，并且这些连接-活动关系的性质随着感觉信息处理中区域角色的变化而变化。最后，我们表明，个体 ISC 的独特空间分布与其大小无关，也与其 RSFC 概况相关。这些发现将 ISC 局部个体差异的报告背景化，认为其可能反映了静息大脑功能中更大的网络水平变化，并详细说明了大脑处理复杂感觉信息的能力如何与其基线功能组织相关联。
When exposed to the same sensory event, some individuals are bound to have less typical experiences than others. Previous research has investigated this phenomenon by showing that the typicality of one’s sensory experience is associated with the typicality of their stimulus-evoked brain activity (as measured by intersubject correlation, or ISC). Individual differences in ISC have recently been attributed to variability in focal neural processing. However, the extent to which these differences reflect purely intra-regional variability versus variation in the brain’s baseline ability to transmit information between regions has yet to be established. Here, we show that an individual’s degree and spatial distribution of ISC are closely related to their brain’s functional organization at rest. Using resting state and movie watching fMRI data from the Human Connectome Project, we reveal that resting state functional connectivity (RSFC) profiles can be used to predict cortex-wide ISC. Similar region-level analyses demonstrate that the levels of ISC exhibited by brain regions during movie watching are associated with their connectivity to other regions at rest, and that the nature of these connectivity-activity relationships varies as a function of regional roles in sensory information processing. Finally, we show that an individual’s unique spatial distribution of ISC, independent of its magnitude, is also related to their RSFC profile. These findings contextualize reports of localized individual differences in ISC as potentially reflecting larger, network-level alterations in resting brain function and detail how the brain’s ability to process complex sensory information is linked to its baseline functional organization.
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