Non-Covalent Interactions of a Neuroprotective Peptide Revealed by Photodissociative Cross-Linking in the Gas Phase
Non-Covalent Interactions of a Neuroprotective Peptide Revealed by Photodissociative Cross-Linking in the Gas Phase
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DOI：
10.1002/chem.201802174
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发表时间：
2018-07-02
影响因子：
4.3
通讯作者：
Turecek, Frantisek
中科院分区：
文献类型：
--
作者：
Liu, Yang;Ramey, Zachary;Turecek, Frantisek
用二氮丙啶基团选择性地标记小神经保护肽Cys-Ala-Gln-Lys（CAQK），并研究其与模型靶肽的光化学交联。结合Born-Oppenheimer分子动力学的实验结果揭示了与靶肽中的氨基酸残基结合的结构偏好。目标肽序列和N-和C-末端修饰的影响进行了讨论。
The small neuroprotective peptide Cys-Ala-Gln-Lys (CAQK) was selectively tagged with a diazirine group and its photochemical cross-linking was studied with model target peptides. Experimental results in combination with Born-Oppenheimer molecular dynamics revealed the structural preferences for binding to the amino acid residues in the target peptides. Effects of the target peptide sequence and N- and C-terminal modifications are discussed.