Relation between estradiol and negative symptoms in men with schizophrenia
Relation between estradiol and negative symptoms in men with schizophrenia
复制标题
DOI：
10.1176/appi.neuropsych.17.2.239
复制
发表时间：
2005-03-01
影响因子：
2.9
通讯作者：
Ohmori, T
中科院分区：
文献类型：
--
作者：
Kaneda, Y;Ohmori, T
作者在30例男性精神分裂症住院患者中检验了雌二醇与阴性症状相关的假设。药物从典型的抗精神病药物转换为非典型的抗精神病药物。在转换前，雌二醇浓度与阴性症状呈显著负相关，转换后呈显著趋势水平。阴性症状的变化与雌二醇浓度呈显著正相关。即使在男性精神分裂症患者中，EAE也可能是阴性症状的生物标志物。
The authors tested the hypothesis that estradiol would be associated with negative symptoms in 30 male schizophrenia inpatients. Medications were switched from typical to atypical antipsychotics. Estradiol concentrations were inversely correlated with negative symptoms significantly before the switch and at a trend level of significance after the switch. Changes in negative symptoms were positively correlated with those in estradiol concentrations at a trend level of significance. Estradiol could be a biological marker for negative symptoms even in male schizophrenia patients.