Cyclothymic-depressive-anxious temperament pattern is related to suicide risk in 346 patients with major mood disorders
Cyclothymic-depressive-anxious temperament pattern is related to suicide risk in 346 patients with major mood disorders
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DOI：
10.1016/j.jad.2011.11.011
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发表时间：
2012-02-01
影响因子：
6.6
通讯作者：
Girardi, Paolo
中科院分区：
文献类型：
--
作者：
Pompili, Maurizio;Innamorati, Marco;Girardi, Paolo
背景：自杀行为不仅是精神病学中最令人担忧的症状之一，而且当前重大抑郁发作是自杀受害者和未遂者中最常见的医学状况。本研究的目的是探讨情绪性气质的个体特征、哥特兰男性抑郁量表(GSMD)测量的非典型抑郁症状、绝望感与重度情绪障碍患者自杀行为之间的关系。所有患者接受TEMPS-A、GSMD、Beck无望量表(BHS)和迷你国际神经精神病学访谈(MINI)。结果：两步聚类分析显示，患者反应集内有两组：环状胸腺抑郁焦虑组和胸腺增高组。超过81%的具有环状胸腺抑郁焦虑气质的患者在Mini上有轻微到严重的自杀风险，而在常见的环状胸腺抑郁焦虑气质患者中，只有约42%的患者BHS评分达到或超过9分，而在普遍的胸腺气质患者中，只有13%的患者有BHS评分。此外，环状胸腺抑郁焦虑气质患者的GSMD比高胸腺气质患者更高。局限性：本研究的相关性限制了得出因果结论。结论：我们的结果表明，情感气质测量和哥特兰男性抑郁量表可以作为筛选和识别有更高自杀行为风险的情感性障碍患者的有用工具。(C)2011爱思唯尔B.V.保留所有权利。
Background: Suicidal behavior is one of the most alarming signs not only in psychiatry, and current major depressive episode is the most frequent medical condition among suicide victims and attempters. The aim of the study was to investigate the relationship between the individual pattern of affective temperaments, non-typical symptoms of depression as measured with the Gotland Scale for Male Depression (GSMD), hopelessness and suicidal behavior in major mood disorder patients.Methods: Participants were 346 adult inpatients (151 men and 195 women) with major mood disorders consecutively admitted to the Department of Psychiatry of the Sant'Andrea University Hospital in Rome, Italy. All the patients were administered the TEMPS-A, the GSMD, and the Beck Hopelessness Scale (BHS) and the Mini International Neuropsychiatric Interview (MINI).Results: A Two Step Cluster Analysis procedure, performed to reveal natural groupings within patients' response set, indicated that there were 2-groups: a cyclothymic-depressive-anxious group and a hyperthymic group. More than 81% of the patients with prevailing cyclothymic-depressive-anxious temperament had mild to severe suicidal risk on the MINI vs. only around 42% of the patients with prevailing hyperthymic temperament Sixty-four percent of patients with prevailing cyclothymic-depressive-anxious temperament had BHS scores of 9 or higher versus only 13% of patients with prevailing hyperthymic temperament. Also, patients with prevailing cyclothymic-depressive-anxious temperament more likely had higher GSMD than patients with prevailing hyperthymic temperament.Limitations: The correlational nature of the study limits causal conclusions to be drawn.Conclusions: Our results indicate that affective temperament measure along with Gotland Scale for Male Depression could be useful tools in screening and identifying those affective disorder patients who are at higher risk of suicidal behavior. (C) 2011 Elsevier B.V. All rights reserved.