Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint
Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint
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DOI：
10.1016/j.dnarep.2008.08.016
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发表时间：
2008-12-01
期刊：
影响因子：
3.8
通讯作者：
Downs, Jessica A.
中科院分区：
文献类型：
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作者：
Downs, Jessica A.
近年来，染色质及其调节在DNA修复过程中的作用越来越被人们所了解。已经鉴定了许多有助于对DNA损伤的细胞反应的组蛋白修饰，包括组蛋白H3在赖氨酸56处的乙酰化。H3 K56乙酰化通常发生在S期，但在DNA损伤的存在下持续存在。在没有这种修饰的情况下，DNA损伤后的细胞存活受损。最近的两个报告提供了更多的见解如何H3 K56乙酰化功能在DNA损伤反应。特别是，这种修饰对于正常的复制偶联核小体组装以及修复后DNA损伤位点的核小体组装都很重要。(C)2008 Elsevier B.V.保留所有权利。
The role of chromatin and its modulation during DNA repair has become increasingly understood in recent years. A number of histone modifications that contribute towards the cellular response to DNA damage have been identified, including the acetylation of histone H3 at lysine 56. H3 K56 acetylation occurs normally during S phase, but persists in the presence of DNA damage. In the absence of this modification, cellular survival following DNA damage is impaired. Two recent reports provide additional insights into how H3 K56 acetylation functions in DNA damage responses. in particular, this modification appears to be important for both normal replication-coupled nucleosome assembly as well as nucleosome assembly at sites of DNA damage following repair. (C) 2008 Elsevier B.V. All rights reserved.