Ferrous iron uptake by a magnesium transport system is toxic for Escherichia coli and Salmonella typhimurium
Ferrous iron uptake by a magnesium transport system is toxic for Escherichia coli and Salmonella typhimurium
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DOI：
10.1128/jb.179.19.6201-6204.1997
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发表时间：
1997-10-01
影响因子：
3.2
通讯作者：
Hantke, K
中科院分区：
文献类型：
--
作者：
Hantke, K
在低镁浓度下，大肠杆菌和鼠伤寒沙门氏菌LT2积累二价铁的亚铁运输系统费独立。在镁转运基因corA突变的突变株积累较少的亚铁比亲本菌株。corA（+）和corA菌株在好氧条件下对亚铁的敏感性也不同。corA突变体比其亲本corA（+）菌株对亚铁的抗性更强。部分二价铁的积累可以通过添加镁来消除。当三价铁被铁载体铁色素吸收时，被追逐的铁要少得多。这些结果可能表明，这些系统吸收的铁的细胞内代谢不同，它取决于铁的摄取途径。
At low magnesium concentrations, Escherichia coli and Salmonella typhimurium LT2 accumulate ferrous iron independent of the ferrous iron transport system fee. Mutant strains with mutations in the magnesium transport gene corA accumulated less ferrous iron than the parent strains. corA(+) and corA strains also differed in their sensitivity to ferrous iron under oxic conditions. corA mutants were more resistant to ferrous iron than their parent corA(+) strains. Part of the ferrous iron accumulated can be chased by the addition of magnesium. Much less iron was chased when ferric iron was taken up by the siderophore ferrichrome. These results may indicate that the intracellular metabolism of the iron taken up by these systems differs and that it depends on the uptake route of the iron.