Facile synthesis of polymer core@silver shell hybrid nanoparticles with super surface enhanced Raman scattering capability
Facile synthesis of polymer core@silver shell hybrid nanoparticles with super surface enhanced Raman scattering capability
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轻松合成具有超表面增强拉曼散射能力的聚合物核@银壳杂化纳米粒子
DOI：
10.1016/j.jcis.2012.11.003
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发表时间：
2013-03-01
影响因子：
9.9
通讯作者：
Epple, Matthias
中科院分区：
文献类型：
--
作者：
Huo, Da;He, Jian;Epple, Matthias
采用两步种子介导法合成了银纳米壳。聚合物核由超细金纳米粒子（NPs）修饰的壳聚糖-聚（丙烯酸）纳米粒子（CS-PAA NPs）组成。然后，银沉积在金核上导致种子增大，最后在CS-PAA NPs表面形成银壳，得到SNSs。透射电子显微镜（TEM）显示SNSs具有离散的银壳层和一些孔隙和间隙，这些孔隙和间隙可以作为“热点”，通过调节银壳层的覆盖率，这些SNSs具有很大的潜力，可以用作波长范围从可见光到红外（700-1000 nm）的Sers基底。以二苄基二硫化物（DBDS）为指示剂的Sers实验表明，所得到的SNSs允许产生高度一致的拉曼信号增强，低至nM浓度的DBDS。考虑到聚合物核的良好生物相容性和它们的小尺寸，这些SNSs是非常理想的候选者，作为高性能Sers分析的增强剂和作为生物医学成像中的Sers光学标记。(C)2012 Elsevier Inc. All rights reserved.
Silver nano-shells (SNSs) were synthesized via a two-step seeds-mediated method. Polymer cores were composed of ultrafine gold nanoparticles (NPs) modified chitosan-poly(acrylic acid) nanoparticles (CS-PAA NPs). Then, deposition of silver upon gold nucleus leads to the seed enlargement and finally forms silver shell on the surface of CS-PAA NPs to get SNSs. Transmission electron microscope (TEM) showed SNSs had a discrete silver shell plus some pores and gaps, which could acted as "hot spots" and provided the great potential of these SNSs to be used as SERS substrates with wavelength ranging from visible to infrared region (700-1000 nm) by tuning shell coverage of silver. SERS experiments with dibenzyl disulphide (DBDS) as the indicator showed that the resulting SNSs allowed the production of highly consistent enhancement of the Raman signals down to nM concentrations of DBDS. Considering the excellent biocompatibility of polymer core and their small size, these SNSs are highly desirable candidates as the enhancers for high performance SERS analysis and as SERS optical labels in biomedical imaging. (C) 2012 Elsevier Inc. All rights reserved.