C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
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DOI：
10.1016/j.cell.2010.11.036
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发表时间：
2010-12-23
期刊：
影响因子：
64.5
通讯作者：
Spiegelman BM
中科院分区：
文献类型：
--
作者：
Boström P;Mann N;Wu J;Quintero PA;Plovie ER;Panáková D;Gupta RK;Xiao C;MacRae CA;Rosenzweig A;Spiegelman BM
心脏具有响应运动而增大尺寸的能力，但对生理性肥大的转录机制知之甚少。成年心肌细胞最近也被证明具有增殖的潜力，这一过程对再生医学非常重要。使用独特的基于RT-PCR的针对所有转录组分的筛选，我们发现C/EBPβ随着运动而下调，而CITED 4的表达增加。在体外和体内，C/EBPβ的降低导致了耐力运动伴随心肌细胞肥大和增殖的表型。这种增殖是介导的，至少部分是由增加的CITED 4。重要的是，心脏C/EBPβ水平降低的小鼠在压力超负荷时表现出对心力衰竭的实质性抵抗。这些数据表明，C/EBPβ抑制成年哺乳动物心脏中的心肌细胞生长和增殖，并且C/EBPβ的减少是生理性肥大和增殖的中心信号。
The heart has the ability to grow in size in response to exercise, but little is known about the transcriptional mechanisms underlying physiological hypertrophy. Adult cardiomyocytes have also recently been proven to hold the potential for proliferation, a process which could be of great importance for regenerative medicine. Using a unique RT-PCR based screen against all transcriptional components, we showed that C/EBPβ was down-regulated with exercise, while the expression of CITED4 was increased. Reduction of C/EBPβ in vitro and in vivo resulted in a phenocopy of endurance exercise with cardiomyocyte hypertrophy and proliferation. This proliferation was mediated, at least in part by the increased CITED4. Importantly, mice with reduced cardiac C/EBPβ levels displayed substantial resistance to cardiac failure upon pressure overload. These data indicate that C/EBPβ represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/EBPβ is a central signal in physiologic hypertrophy and proliferation.
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影响因子：
64.5
作者：
Bersell, Kevin;Arab, Shima;Kuehn, Bernhard
通讯作者：
Kuehn, Bernhard
DOI：
10.1073/pnas.0603615103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Arany, Zoltan;Novikov, Mikhail;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
4.3
作者：
Sebastian, Thomas;Johnson, Peter F.
通讯作者：
Johnson, Peter F.
影响因子：
37.8
作者：
Taniike, Masayuki;Yamaguchi, Osamu;Otsu, Kinya
通讯作者：
Otsu, Kinya
Notch 激活静止心肌细胞的细胞周期重入和进展。
DOI：
10.1083/jcb.200806104
发表时间：
2008-10-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Campa VM;Gutiérrez-Lanza R;Cerignoli F;Díaz-Trelles R;Nelson B;Tsuji T;Barcova M;Jiang W;Mercola M
通讯作者：
Mercola M