T-1 rho-relaxation in articular cartilage: Effects of enzymatic degradation
T-1 rho-relaxation in articular cartilage: Effects of enzymatic degradation
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DOI：
10.1002/mrm.1910380602
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发表时间：
1997-12-01
影响因子：
3.3
通讯作者：
Leigh, JS
中科院分区：
文献类型：
--
作者：
Duvvuri, U;Reddy, R;Leigh, JS
本文应用旋转坐标系中的自旋-晶格弛豫（T-1 rho）色散谱和成像技术研究了正常和酶降解的牛关节软骨。（类似于60至类似于130 ms），蛋白聚糖降解样本的T-1 rho值比胶原降解或正常样本高33%，T-1 rho加权图像显示了传统T-1或T-2加权图像中未发现的结构，我们的研究结果表明，T-1 ρ测量是选择性敏感的蛋白多糖含量。这种方法在区分与骨关节炎相关的软骨早期退行性变化的潜力进行了讨论。
Spin-lattice relaxation in the rotating frame (T-1 rho) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage, Normal specimens demonstrate significant T-1 rho ''dispersion'' (similar to 60 to similar to 130 ms) in the 100 Hz to 9 kHz frequency range, Proteoglycan-degraded specimens have 33% greater T-1 rho values than collagen-degraded or normal samples, T-1 rho-weighted images reveal structure not found in conventional T-1- or T-2-weighted images, Our results suggest that T-1 rho measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.