Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
复制标题
小鼠胸腺的冷冻保存会消耗胸腺细胞，但支持移植时的免疫重建。
DOI：
10.1002/eji.202350546
复制
发表时间：
2023
影响因子：
5.4
通讯作者：
Chawda MM
中科院分区：
文献类型：
--
作者：
Chawda MM
小鼠胸腺的冷冻保存耗尽供体胸腺细胞，但在解冻后移植到无胸腺小鼠中时保留了胸腺功能。在新鲜和冷冻/解冻移植物之间未观察到免疫重建差异，表明供体胸腺细胞耗竭不影响结果。因此，冷冻保存胸腺可能会改善胸腺移植患者的预后。
Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.