I-MOVE multicentre case-control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination?
I-MOVE multicentre case-control study 2010/11 to 2014/15: Is there within-season waning of influenza type/subtype vaccine effectiveness with increasing time since vaccination?
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DOI：
10.2807/1560-7917.es.2016.21.16.30201
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发表时间：
2016-04-21
期刊：
影响因子：
19
通讯作者：
Moren, A.
中科院分区：
文献类型：
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作者：
Kissling, E.;Nunes, B.;Moren, A.
自2008/9流感季节以来，I-MOVE多中心病例对照研究测量了流感疫苗对经医学检查的流感样疾病（ILI）实验室确认为流感的有效性（VE）。在2011/12年，欧洲的研究报告说，在该季节内，抗甲型H3 N2流感的VE下降。使用2010/11年至2014/15年的合并I-MOVE数据，我们研究了自接种疫苗以来的时间对流感类型/亚型特异性VE的影响。我们使用限制性三次样条，控制潜在的混杂因素（年龄、性别、发病时间、慢性疾病），按接种疫苗后的时间对流感类型/亚型特异性VE进行建模。甲型（H3 N2）、甲型（H1N1）pdm 09和B流感的每项分析均包括10，000多例ILI病例;分别有4，759、3，152和3，617例流感阳性病例。疫苗接种后38天，抗甲型H3 N2流感病毒的VE达到50.6%（95%CI：30.0-65.1），从111天开始下降至0%（95%CI：-18.1-15.2）。在第54天，针对甲型流感（H1N1）pdm 09的VE达到55.3%（95%CI：37.9-67.9），并且保持在该值和50.3%（95%CI：34.8-62.1）之间，直到季节结束。抗流感B的VE从接种后44天的70.7%（95% CI：51.3-82.4）下降至季节结束时的21.4%（95% CI：-57.4-60.8）。评估疫苗接种活动策略是否需要随着时间的推移修改更多关于VE的证据，因为疫苗接种是迫切需要的。
Since the 2008/9 influenza season, the I-MOVE multicentre case-control study measures influenza vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE against influenza A(H3N2) within the season. Using combined I-MOVE data from 2010/11 to 2014/15 we studied the effects of time since vaccination on influenza type/subtype-specific VE. We modelled influenza type/subtype-specific VE by time since vaccination using a restricted cubic spline, controlling for potential confounders (age, sex, time of onset, chronic conditions). Over 10,000 ILI cases were included in each analysis of influenza A(H3N2), A(H1N1) pdm09 and B; with 4,759, 3,152 and 3,617 influenza positive cases respectively. VE against influenza A(H3N2) reached 50.6% (95% CI: 30.0-65.1) 38 days after vaccination, declined to 0% (95% CI: -18.1-15.2) from 111 days onwards. At day 54 VE against influenza A(H1N1) pdm09 reached 55.3% (95% CI: 37.9-67.9) and remained between this value and 50.3% (95% CI: 34.8-62.1) until season end. VE against influenza B declined from 70.7% (95% CI: 51.3-82.4) 44 days after vaccination to 21.4% (95% CI: -57.4-60.8) at season end. To assess if vaccination campaign strategies need revising more evidence on VE by time since vaccination is urgently needed.