Transplantation effects of a unique major histocompatibility complex class I mutation.
Transplantation effects of a unique major histocompatibility complex class I mutation.
复制标题
独特的主要组织相容性复合物 I 类突变的移植效果。
DOI：
10.1097/00007890-199208000-00031
复制
发表时间：
1992
期刊：
影响因子：
6.2
通讯作者：
Nathenson,SG
中科院分区：
文献类型：
--
作者：
Hasenkrug,KJ;Stimpfling,JH;Winn,HJ;Nathenson,SG
本研究描述了一种新的MHC I类小鼠突变体，由于其细胞对单克隆抗体的反应性丧失而被发现。该突变发生在H-2K[度]分子中，并且是第一个被描述的体内突变，其具有单个改变的氨基酸残基（氨基酸107），远离被认为是肽或TCR接触的区域。然而，从突变体移植到亲本的皮肤会被CD8+ t细胞排斥。在互反方向上，突变体对亲代皮肤移植物表现出部分耐受性，这表明突变体在选择野生型K[度]分子特异性的同种异体反应性t细胞方面效率低下。
: This study describes a novel MHC class I mouse mutant that was discovered because of loss of reactivity of its cells to monoclonal antibodies. The mutation occurred in the H-2K [degrees] molecule and is the first in vivo mutation described that has a single altered amino acid residue (amino acid 107) distant from the regions considered to be peptide or TCR contacts. Nevertheless, skin grafts from the mutant to the parent are rejected by CD8+ T-cells. In the reciprocal direction, the mutant shows partial tolerance to parental skin grafts, suggesting that the mutant is inefficient in selecting alloreactive T-cells specific for the wild-type K [degrees] molecule.