Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively
Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively
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DOI：
10.1128/jcm.37.12.3940-3945.1999
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发表时间：
1999-12-01
影响因子：
9.4
通讯作者：
Hierholzer, JC
中科院分区：
文献类型：
--
作者：
De Jong, JC;Wermenbol, AG;Hierholzer, JC
从大量的人类免疫缺陷病毒（HN）感染的个人的腺病毒（Ad）分离株进行了比较血清学和遗传学与Ad分离免疫功能正常的患者。在1982年和1994年之间，粪便和尿液样本从137例艾滋病住院在荷兰产生了143个Ad菌株。1992年和1993年从英国曼彻斯特的35例HIV阳性患者中分离出40株Ad，其中84%属于D型，3%属于C型。在后者中，5%属于D种，49%属于C种。从AIDS病人粪便标本中分离的两株Ad代表新的血清型：B1亚种的候选Ad血清型50（原型株，Wan）和D种的候选Ad血清型51（原型株，Bom）。Wan和Bom株的DNA限制性内切酶酶谱与所有已建立的原型株的DNA限制性内切酶谱不同。
Adenovirus (Ad) isolates from a large number of human immunodeficiency virus (HN)-infected individuals were compared serologically and genetically with Ad isolates from immunocompetent patients. Between 1982 and 1994, stool and urine samples from 137 subjects with AIDS hospitalized in The Netherlands yielded 143 Ad strains. Forty additional Ad strains were obtained from 35 HIV-positive patients in Manchester, United Kingdom, in 1992 and 1993, Of these 183 HIV-associated Ad strains, 84% belonged to species D and 3% belonged to species C, These strains were compared with 2,301 Ad strains collected during general diagnostic examinations in The Netherlands from 1973 to 1992. Of the latter strains, 5% belonged to species D and 49% belonged to species C. Two of the Ads isolated from fecal specimens of AIDS patients represent new serotypes: candidate Ad serotype 50 (prototype strain, Wan) of subspecies B1 and candidate Ad serotype 51 (prototype strain, Bom) of species D, The DNA restriction enzyme patterns of strains Wan and Bom differed from the patterns of all established prototypes.