ABNORMAL EXPRESSION OF ACTIN IN LYMPHOCYTES OF ALZHEIMERS-DISEASE AND DOWN-SYNDROME PATIENTS
ABNORMAL EXPRESSION OF ACTIN IN LYMPHOCYTES OF ALZHEIMERS-DISEASE AND DOWN-SYNDROME PATIENTS
复制标题
DOI：
10.1016/0165-5728(92)90013-b
复制
发表时间：
1992-06-01
影响因子：
3.3
通讯作者：
EMILE, J
中科院分区：
文献类型：
--
作者：
JABBOUR, W;POUPLARDBARTHELAIX, A;EMILE, J
阿尔茨海默病（AD）是一种伴有多种免疫紊乱的中枢神经系统退行性疾病，AD与唐氏综合征（DS）之间存在许多共同特征。淋巴细胞蛋白的高分辨率双向电泳显示AD和DS的肌动蛋白异常：双肌动蛋白点而不是对照中观察到的单点。通过脉冲追踪实验研究了这种双重形式，似乎与影响肌动蛋白翻译后修饰的细胞外因子有关。这些结果与阿尔茨海默病和退行性痴呆中观察到的免疫紊乱一致，也与阿尔茨海默病是一种全身性和脑性疾病的既定假设一致。
Alzheimer's disease (AD) is a degenerative disorder of the central nervous system accompanied by several immunological disturbances and a number of common features exist between AD and Down's syndrome (DS). High resolution two-dimensional electrophoresis of lymphocyte proteins demonstrates an actin abnormality in AD and DS: a double actin spot instead of the single spot observed in controls. This dual form was studied by pulse-chase experiments and seems to be related to extracellular factors which influence the post-translational modification of actin. These results agree with the immunological disturbances observed in AD and DS, and with the well established hypothesis that AD is a systemic as well as cerebral disease.