Distinct Patterns of Regional Cerebral Glucose Metabolism in Parkinson's Disease with and without Mild Cognitive Impairment
Distinct Patterns of Regional Cerebral Glucose Metabolism in Parkinson's Disease with and without Mild Cognitive Impairment
复制标题
DOI：
10.1002/mds.22444
复制
发表时间：
2009-04-30
影响因子：
8.6
通讯作者：
Mori, Etsuro
中科院分区：
文献类型：
--
作者：
Hosokai, Yoshiyuki;Nishio, Yoshiyuki;Mori, Etsuro
关于帕金森病（PD）前驱痴呆的临床和神经影像学特征尚未达成共识。为了描述PD伴轻度认知功能障碍（PDMCI）和无认知功能障碍（PDNC）患者的功能性神经影像学特征，我们比较了13例PDMCI患者、27例PDNC患者和13例健康对照者的局部脑葡萄糖代谢（CMRglc）。PDNC患者在额叶和枕叶皮质有有限的低代谢区域。在PDMCI患者中，后皮质区域存在广泛的代谢低下区域，包括颞顶枕交界处、内侧顶叶和颞下皮质。目前的研究结果表明，后皮质功能障碍是主要的神经影像学特征的PD患者的痴呆风险。(C)2009运动障碍协会
There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo-parieto-occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia. (C) 2009 Movement Disorder Society