Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy
Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy
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DOI：
10.1016/j.nmd.2019.09.006
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发表时间：
2019-12-01
影响因子：
2.8
通讯作者：
Takahashi, Yuji
中科院分区：
文献类型：
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作者：
Mori-Yoshimura, Madoka;Mizuno, Yukio;Takahashi, Yuji
贝克肌营养不良症（BMD）和精神障碍之间的关系知之甚少。本研究旨在阐明骨密度是否是精神疾病的危险因素。我们要求遗传学或生化学证实的BMD患者参加研究访谈。同意接受精神测试的参与者接受了智力，心理和神经发育障碍的进一步评估。105例BMD患者（中位年龄37岁）中共有76例（73%）完成了访谈。其中6人患有发育障碍（精神发育迟滞，广泛性发育障碍），33/76（43%）在学校经历过欺凌，11人表现出有问题的行为，如逃课和暴力事件，16人有精神障碍（精神分裂症谱系，5例;抑郁谱系，4例;应激相关障碍，3例;强迫症及相关障碍，2例;躯体症状和相关障碍，2;双相情感障碍和相关障碍，1）。平均智商正常，而13/40（32.5%）的参与者处于抑郁状态。20/40（50%）的患者存在高度特质焦虑，而15/40（38.5%）的患者处于焦虑状态。对14名参与者的MRI数据进行回顾，发现脑萎缩仅由BMD引起，与任何其他并发症无关。我们的研究结果表明，BMD患者有发生精神疾病的风险。身体障碍或欺凌可能会影响他们的心理状态，因为他们中的许多人有高特质焦虑。家长、教师和支持者应注意BMD患者的日常环境，并提供支持，帮助他们科普压力。(C)2019作者由爱思唯尔公司出版。这是一个开放获取的文章下，CC BY-NC-ND许可证。(http：//creativecommons.org/licenses/by-nc-nd/4.0/）
Little is known about the relationship between Becker Muscular Dystrophy (BMD) and mental disorders. This study aimed to clarify whether BMD is a risk factor for psychiatric diseases. We asked genetically or immunohistochemically confirmed BMD patients to participate in the study interview. Participants who consented to psychiatric tests underwent further assessments of intellectual, psychological, and neurodevelopmental disorders. In total, 76 (73%) of 105 BMD patients (median age, 37 years) completed the interview. Of these, 6 had developmental disorders (mental retardation, pervasive developmental disorder), 33/76 (43%) experienced bullying in school, 11 exhibited problematic behaviors such as cutting class and violent incidents, and 16 had psychiatric disorders (schizophrenia spectrum, 5; depressive spectrum, 4; stress-related disorders, 3; obsessive-compulsive and related disorders, 2; somatic symptom and related disorders, 2; bipolar and related disorders, 1). Mean IQ was normal, whereas 13/40 (32.5%) of participants were in a depressive state. High trait anxiety was found in 20/40 (50%) of patients, while 15/40 (38.5%) were in an anxious state. Review of MRI data from 14 participants revealed brain atrophy caused solely by BMD and unrelated to any other complication. Our findings suggest that BMD patients are at risk of developing psychiatric disorders. Physical handicap or bullying may influence their mental state, as many of them have high trait anxiety. Parents, teachers, and supporters should be mindful of the daily environment of BMD patients and provide support to help them cope with stress. (C) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)