White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans
White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans
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DOI：
10.1093/aje/kwi326
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发表时间：
2005-12-01
影响因子：
5
通讯作者：
Samet, JM
中科院分区：
文献类型：
--
作者：
Jee, SH;Park, JY;Samet, JM
作者对437，454名年龄在40-95岁之间的韩国人进行了一项为期10年的前瞻性队列研究，研究死亡率与白色血细胞计数的关系，这些人接受了国家健康保险公司的健康保险，并在1993年或1995年进行了白色血细胞测量的医学评估。主要结果指标为全因死亡率、所有癌症和所有动脉粥样硬化性心血管疾病（ASCVD）。使用考克斯比例风险模型计算风险比和95%置信区间，并对年龄和潜在混杂因素进行调整。在随访期间，发生了48，757例死亡，其中15，507例死于癌症，11，676例死于ASCVD。对于男性和女性，白色血细胞计数与全因死亡率和ASCVD死亡率相关，但与癌症死亡率无关。在健康的非吸烟者中，观察到男性（最高与最低五分位数：风险比= 2.10，95%置信区间：1.50，2.94）和女性（风险比= 1.35，95%置信区间：1.17，1.56）中较高的白色血细胞计数与较高的ASCVD风险之间存在分级关联。在健康吸烟者中，男性中也观察到较高的白色血细胞计数与较高的ASCVD风险之间存在分级关联（最高与最低五分位数：风险比= 1.46，95%置信区间：1.25，1.72）。这些结果表明，白色血细胞计数是全因死亡率和ASCVD死亡率的独立危险因素。
The authors conducted a 10-year prospective cohort study of mortality in relation to white blood cell counts of 437,454 Koreans, aged 40-95 years, who received health insurance from the National Health Insurance Corporation and were medically evaluated in 1993 or 1995, with white blood cell measurement. The main outcome measures were mortality from all causes, all cancers, and all atherosclerotic cardiovascular diseases (ASCVD). Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards models with adjustment for age and potential confounders. During follow-up, 48,757 deaths occurred, with 15,507 deaths from cancer and 11,676 from ASCVD. For men and women, white blood cell count was associated with all-cause mortality and ASCVD mortality but not with cancer mortality. In healthy nonsmokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was observed in men (highest vs. lowest quintile: hazard ratio = 2.10, 95% confidence interval: 1.50, 2.94) and in women (hazard ratio = 1.35, 95% confidence interval: 1.17, 1.56). In healthy smokers, a graded association between a higher white blood cell count and a higher risk of ASCVD was also observed in men (highest vs. lowest quintile: hazard ratio = 1.46, 95% confidence interval: 1.25, 1.72). These findings indicate that the white blood cell count is an independent risk factor for all-cause mortality and for ASCVD mortality.