Effect of L-Leucine Graft Content on Aqueous Solution Behavior and Membrane-Lytic Activity of a pH-Responsive Pseudopeptide
Effect of L-Leucine Graft Content on Aqueous Solution Behavior and Membrane-Lytic Activity of a pH-Responsive Pseudopeptide
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DOI：
10.1021/bm900534j
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发表时间：
2009-09-01
影响因子：
6.2
通讯作者：
Slater, Nigel K. H.
中科院分区：
文献类型：
--
作者：
Chen, Rongjun;Khormaee, Sariah;Slater, Nigel K. H.
通过将L-亮氨酸接枝到线性假肽聚L-赖氨酸异邻苯二甲酰胺的羧酸侧基上，合成了一系列pH响应性聚合物。接枝水溶液的性质，细胞膜破坏活性，并在体外细胞毒性的程度的影响进行了研究，通过紫外可见和荧光光谱，溶血，阿利兰染色，碘化丙啶荧光测定。聚（L-赖氨酸异邻苯二甲酰胺）的修饰
A series of pH-responsive polymers have been synthesized by grafting L-leucine onto the pendant carboxylic acid groups of the linear pseudopeptide, poly(L-lysine iso-phthalamide). The effect of the degree of grafting on aqueous solution properties, cell membrane-disruptive activity, and in vitro cytotoxicity was examined by UV-visible and fluorescence spectroscopy, hemolysis, alamar blue staining, and propidium iodide fluorescence assays. Modification of poly(L-lysine iso-phthalamide) with