Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy.
Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy.
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DOI：
10.1093/humupd/dmp046
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发表时间：
2010-07
影响因子：
13.3
通讯作者：
Roberts CT
中科院分区：
文献类型：
--
作者：
Pringle KG;Kind KL;Sferruzzi-Perri AN;Thompson JG;Roberts CT
在妊娠早期，绒毛外细胞滋养层细胞阻塞子宫螺旋小动脉，在妊娠早期创造低氧环境，这对妊娠成功至关重要。特别是，在妊娠早期，滋养层细胞的浅浸润和子宫螺旋动脉的血管重建缺陷可能导致胎盘灌注受损和妊娠后期的慢性胎盘缺血和缺氧，从而导致不良妊娠结局。低氧诱导因子（hypoxia inducible factors，HIFs）是低氧反应的关键介质。我们的目的是阐明HIF的调节机制以及它们在正常和病理妊娠中控制胎盘分化、生长和功能中可能发挥的作用。查阅Pubmed数据库以识别最相关的已发表文章。使用的检索词为氧气、胎盘、滋养层、妊娠、HIF和缺氧。HIF能够在正常和异常胎盘分化、生长和功能的所有方面发挥作用;在妊娠早期（生理低氧）、妊娠中晚期（其中胎盘有充足的血液和氧气供应）和胎盘缺氧/缺血并发的病理妊娠中。在正常妊娠期间，HIF可能对氧、激素、细胞因子和生长因子的复杂变化作出反应，以调节胎盘侵袭、分化、转运和血管形成。在妊娠期间不断变化的环境中，HIF似乎是胎盘发育和功能的关键介质，因此可能是正常和不良妊娠结局的重要因素。
In the first trimester the extravillous cytotrophoblast cells occlude the uterine spiral arterioles creating a low oxygen environment early in pregnancy, which is essential for pregnancy success. Paradoxically, shallow trophoblast invasion and defective vascular remodelling of the uterine spiral arteries in the first trimester may result in impaired placental perfusion and chronic placental ischemia and hypoxia later in gestation leading to adverse pregnancy outcomes. The hypoxia inducible factors (HIFs) are key mediators of the response to low oxygen. We aimed to elucidate mechanisms of regulation of HIFs and the role these may play in the control of placental differentiation, growth and function in both normal and pathological pregnancies. The Pubmed database was consulted for identification of the most relevant published articles. Search terms used were oxygen, placenta, trophoblast, pregnancy, HIF and hypoxia. The HIFs are able to function throughout all aspects of normal and abnormal placental differentiation, growth and function; during the first trimester (physiologically low oxygen), during mid-late gestation (where there is adequate supply of blood and oxygen to the placenta) and in pathological pregnancies complicated by placental hypoxia/ischemia. During normal pregnancy HIFs may respond to complex alterations in oxygen, hormones, cytokines and growth factors to regulate placental invasion, differentiation, transport and vascularization. In the ever-changing environment created during pregnancy, the HIFs appear to act as key mediators of placental development and function and thereby are likely to be important contributors to both normal and adverse pregnancy outcomes.
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影响因子：
3.6
作者：
Clark, DE;Smith, SK;Charnock-Jones, DS
通讯作者：
Charnock-Jones, DS
DOI：
10.1073/pnas.93.23.12969
发表时间：
1996-11-12
影响因子：
11.1
作者：
Arany, Z;Huang, LE;Livingston, DM
通讯作者：
Livingston, DM
影响因子：
4.8
作者：
Cockman, ME;Masson, N;Maxwell, PH
通讯作者：
Maxwell, PH
影响因子：
5.5
作者：
Baumann, Marc U.;Zamudio, Stacy;Illsley, Nicholas P.
通讯作者：
Illsley, Nicholas P.
影响因子：
5.3
作者：
Chan, DA;Sutphin, PD;Giaccia, AJ
通讯作者：
Giaccia, AJ