Metabolomic applications in nutritional research
Metabolomic applications in nutritional research
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DOI：
10.1017/s0029665108008719
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发表时间：
2008-11-01
影响因子：
7
通讯作者：
Brennan, Lorraine
中科院分区：
文献类型：
--
作者：
Brennan, Lorraine
代谢组学旨在分析生物样品中存在的所有小分子，如生物液体，组织提取物和培养基。将获得的数据与多变量数据分析工具相结合，可以探索由生物治疗引起的变化或由表型引起的变化。近年来，代谢组学在营养学研究中的应用越来越受到人们的关注，由于营养物质与代谢之间的密切关系，代谢组学在营养学研究中的应用具有很大的潜力。然而，为了使代谢组学在这一领域充分发挥潜力，对所面临的挑战保持现实也很重要。这些挑战的例子包括必须清楚地了解人体代谢组学特征变化的原因，肠道微生物对代谢组学特征的影响以及肠道微生物与宿主代谢的相互作用。与人类营养研究特别相关的另一个挑战是与数据的生物学解释有关的困难。尽管存在这些和其他挑战，但仍有一些成功应用于营养研究的例子。人类代谢表型（以代谢组学特征为特征）与饮食偏好之间的联系提出了代谢组学在个性化营养中的潜在作用。
Metabolomics aims to profile all small molecules that are present in biological samples such as biofluids, tissue extracts and culture media. Combining the data obtained with multivariate data analysis tools allows the exploration of changes induced by a biological treatment or changes resulting from phenotype. Recently, there has been a large increase in interest in using metabolomics in nutritional research and because of the intimate relationship between nutrients and metabolism there exists great potential for the use of metabolomics within nutritional research. However, for metabolomics to reach its full potential within this field it is also important to be realistic about the challenges that are faced. Examples of such challenges include the necessity to have a clear understanding of the causes of variation in human metabolomic profiles, the effects of the gut microflora on the metabolomic profile and the interaction of the gut microflora with the host's metabolism. A further challenge that is particularly relevant for human nutritional research is the difficulty associated with biological interpretation of the data. Notwithstanding these and other challenges, several examples of successful applications to nutritional research exist. The link between the human metabolic phenotype, as characterised by metabolomic profiles, and dietary preferences proposes the potential role of metabolomics in personalised nutrition.