Somatomedin: Inhibition of Adenylate Cyclase Activity in Subcellular Membranes of Various Tissues
Somatomedin: Inhibition of Adenylate Cyclase Activity in Subcellular Membranes of Various Tissues
复制标题
生长调节素：抑制各种组织亚细胞膜中的腺苷酸环化酶活性
作者：
G. Tell;P. Cuatrecasas;J. V. Van Wyk;R. Hintz
生长调节素在3和20单位/毫升之间的浓度显着抑制腺苷酸环化酶的基础活性，在粗膜制备获得匀浆的脂肪细胞，肝，脾淋巴细胞的大鼠，软骨细胞和软骨的鸡胚。在存在刺激激素（肾上腺素、前列腺素PGE 1、甲状旁腺激素）的情况下测量的酶活性在这些制剂中也被生长调节素抑制。这些观察结果可能与促生长物质的作用机制和正常调节细胞生长的过程有关。
Somatomedin in concentrations between 3 and 20 units per milliliter significantly inhibits the basal activity of adenylate cyclase in crude membrane preparations obtained from homogenates of fat cells, liver, and spleen lymphocytes of the rat, and from chondrocytes and cartilage of chick embryos. The enzyme activity measured in the presence of stimulating hormones (epinephrine, prostaglandin PGE1, parathyroid hormone) is also inhibited in these preparations by somatomedin. These observations may be relevant in a general way to the mechanism of action of growth-prmoting substances and to the processes which normally regulate cell growth.