CIGARETTE-SMOKE INHALATION AND THE ACUTE AIRWAY RESPONSE
CIGARETTE-SMOKE INHALATION AND THE ACUTE AIRWAY RESPONSE
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DOI：
10.1136/thx.35.4.246
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发表时间：
1980-01-01
期刊：
影响因子：
10
通讯作者：
CLARK, TJH
中科院分区：
文献类型：
--
作者：
HIGENBOTTAM, T;FEYERABAND, C;CLARK, TJH
对 13 名健康吸烟者反复评估了快速连续吸食不同数量（1-4 支）相同香烟以及吸食不同焦油/尼古丁含量的单支香烟的急性气道反应。气道反应各不相同，表明只有 3 名受试者的气道持续变窄。在检测气道反应方面，用力肺活量测定和气道阻力测量之间似乎没有差异。通过静脉血尼古丁或 HbCO 百分比的变化来测量，没有观察到气道反应与吸入肺部的烟雾量之间存在关系。当 5 名吸烟者直接吸入香烟烟雾时，一致观察到急性气道狭窄。正常的吸烟模式包括最初将烟雾吸入口中，然后暂停后吸入用空气稀释的烟雾，这种模式并不总是导致气道变窄，尽管根据静脉血尼古丁的变化评估，吸入的烟雾量与直接吸入的烟雾量相似。烟雾吸入方式影响到达肺部的烟雾不同成分的相对浓度，并且似乎是吸烟引起的急性气道反应的主要决定因素，这与吸烟的数量或烟雾焦油含量无关。烟雾吸入模式可能会影响与吸烟相关的支气管疾病的发病机制。
The acute airway response to smoking varying numbers (1-4) of identical cigarettes in rapid succession and smoking single cigarettes of differing tar/nicotine yields was assessed repeatedly in 13 healthy smokers. The airway response was variable, indicating airway narrowing consistently in only 3 subjects. There appeared no difference between forced spirometry and measurement of airway resistance in detecting the airway response. No relationship was observed between the airway response and amount of smoke inhaled into the lungs as measured by changes in venous blood nicotine or percentage HbCO. When 5 smokers inhaled smoke directly from a cigarette, acute airway narrowing was consistently observed. A normal smoking pattern consisting of an initial drag of smoke into the mouth, followed after a pause by inhalation of smoke diluted with air, did not consistently cause airway narrowing, although similar amounts of smoke as the direct drag were inhaled as assessed by changes in venous blood nicotine. The manner of smoke inhalation affects the relative concentrations of the different constituents of smoke reaching the lungs and appears to be the main determinant of the acute airway response to smoking, which was unrelated to the number of cigarettes smoked or the smoke tar content. Patterns of smoke inhalation may influence the pathogenesis of bronchial disease associated with smoking.