Inflammatory bowel disease.
Inflammatory bowel disease.
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DOI：
10.1146/annurev-immunol-030409-101225
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发表时间：
2010
影响因子：
29.7
通讯作者：
Blumberg RS
中科院分区：
文献类型：
--
作者：
Kaser A;Zeissig S;Blumberg RS
由于对大量肠道炎症动物模型的免疫学研究，在询问作为复杂遗传性状遗传的疾病方面取得了突破性进展，以及开发了独立于培养物的方法来定义肠道微生物群的组成，因此对炎症性肠病（IBD）的见解正在迅速发展。这些进展使人们对肠道微生物群、肠上皮细胞和免疫系统之间的遗传决定的相互作用以及这种相互作用可能被IBD发病机制中的相关环境因素改变的方式有了更深入的了解。本文综述了这些相互作用，并在可能的情况下，从IBD导向的生物治疗中获得的潜在经验教训，这些经验教训可能有助于阐明人类疾病发病机制的核心途径。
Insights into inflammatory bowel disease (IBD) are advancing rapidly owing to immunologic investigations of a plethora of animal models of intestinal inflammation, ground-breaking advances in the interrogation of diseases that are inherited as complex genetic traits, and the development of culture-independent methods to define the composition of the intestinal microbiota. These advances are bringing a deeper understanding to the genetically determined interplay between the commensal microbiota, intestinal epithelial cells, and the immune system and the manner in which this interplay might be modified by relevant environmental factors in the pathogenesis of IBD. This review examines these interactions and, where possible, potential lessons from IBD-directed, biologic therapies that may allow for elucidation of pathways that are central to disease pathogenesis in humans.