Quercetin 3-rhamnoside Exerts Antiinfluenza A Virus Activity in Mice
Quercetin 3-rhamnoside Exerts Antiinfluenza A Virus Activity in Mice
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DOI：
10.1002/ptr.3529
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发表时间：
2012-03-01
影响因子：
7.2
通讯作者：
Kwon, Dur Han
中科院分区：
文献类型：
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作者：
Choi, Hwa Jung;Song, Jae Hyoung;Kwon, Dur Han
我们的前期研究表明槲皮素3-鼠李糖苷（Q3 R）在体外具有抗流感病毒A/WS/33活性。本研究评价了Q3 R对A/WS/33流感病毒感染小鼠的作用。小鼠口服Q3 R（6.25？mg/kg/剂）。h前和每日一次，共6次？在流感病毒感染后30天，体重减轻显著减少，死亡率降低。肺病毒滴度的小鼠杀死6？感染后30天的存活率比安慰剂治疗的对照小鼠低约2000倍，比奥司他韦治疗的小鼠低约2倍。此外，组织学评价表明，Q3 R给药延迟了肺部病变的发展和进展。因此，Q3 R可能是一个有吸引力的领导开发抗流感病毒的药物。版权所有（c）2011约翰威利父子有限公司
Our previous report showed that quercetin 3-rhamnoside (Q3R) possessed antiviral activity against influenza A/WS/33 virus in vitro. The present study evaluated the effect of Q3R on influenza A/WS/33 virus infected mice. Mice orally treated with Q3R (6.25?mg/kg per dose) at 2?h before and once daily for 6?days after influenza virus infection showed significant decreases in weight loss, and decreased mortality. Lung virus titers of mice killed at 6?days after infection were about 2000 times lower than that of the placebo-treated control mice and about two times lower than that for the oseltamivir-treated mice. Furthermore, histological evaluation showed that administration of Q3R delayed the development and progression of pulmonary lesions. Therefore, Q3R could be an attractive lead for the development of antiviral agents against influenza virus. Copyright (c) 2011 John Wiley & Sons, Ltd.