3D Echo-Based Patient-Specific Computational Left Ventricle Models to Quantify Material Properties and Stress/Strain Differences between Ventricles with and without Infarct.
3D Echo-Based Patient-Specific Computational Left Ventricle Models to Quantify Material Properties and Stress/Strain Differences between Ventricles with and without Infarct.
复制标题
DOI：
10.3970/cmes.2014.099.491
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Rui Fan;D. Tang;Jing Yao;Chun Yang;Di Xu
中科院分区：
文献类型：
--
作者：
Rui Fan;D. Tang;Jing Yao;Chun Yang;Di Xu
无创性地识别心脏病发作后心室的材料特性及其梗死面积具有重要的临床应用价值。提出了一种基于回波的计算建模方法，用于使用患者特定数据研究左心室（LV）的力学特性和应力条件。超声数据采集自一名健康志愿者（男性，年龄：58岁）和一名男性患者（年龄：60岁），该患者在超声图像采集前一周患有急性下壁心肌梗死。使用带有3V探头的超声机（E9，GE Mechanical Systems，密尔沃基，威斯康星州）获得标准超声心动图，并将数据分段用于模型构建。建立有限元模型，获得心室应力和应变条件。应用预收缩过程，使得收缩末期压力下的模型心室几何形状与体内数据相匹配。我们的研究结果表明，建模方法有可能被用来确定心室材料的属性。健康左心室（LV 1）的等效杨氏模量值在舒张末期比梗塞左心室（LV 2）的等效杨氏模量值软约30%，但在收缩末期比梗塞左心室（LV 2）的等效杨氏模量值硬约100%。这可以解释为LV 1具有由刚度变化反映的更主动的收缩。使用平均值，在收缩末期，LV 2的纵向曲率比LV 1高164%。LV 2的LV应力比LV 1高82%。在舒张末期，LV 2的L-曲率仍然比LV 1高132%，而LV 2的LV应力仅比LV 1高9%。两个心室之间的纵向曲率和应力差异最大，梗死的LV具有更高的纵向曲率和应力值。需要大规模的研究来进一步证实我们的发现。
Identifying ventricle material properties and its infarct area after heart attack noninvasively is of great important in clinical applications. An echo-based computational modeling approach was proposed to investigate left ventricle (LV) mechanical properties and stress conditions using patient-specific data. Echo data was acquired from one healthy volunteer (male, age: 58) and a male patient (age: 60) who had an acute inferior myocardial infarction one week before echo image acquisition. Standard echocardiograms were obtained using an ultrasound machine (E9, GE Mechanical Systems, Milwaukee, Wisconsin) with a 3V probe and data were segmented for model construction. Finite element models were constructed to obtain ventricle stress and strain conditions. A pre-shrink process was applied so that the model ventricle geometries under end-of-systole pressure matched in vivo data. Our results indicated that the modeling approach has the potential to be used to determine ventricle material properties. The equivalent Young's modulus value from the healthy LV (LV1) was about 30% softer than that of the infarct LV (LV2) at end of diastole, but was about 100% stiffer than that of LV2 at end of systole. This can be explained as LV1 has more active contraction reflected by stiffness variations. Using averaged values, at end-systole, longitudinal curvature from LV2 was 164% higher than that from LV1. LV stress from LV2 was 82% higher than that from LV1. At end-diastole, L-curvature from LV2 was still 132% higher than that from LV1, while LV stress from LV2 was only 9% higher than that from LV1. Longitudinal curvature and stress showed the largest differences between the two ventricles, with the LV with infarct having higher longitudinal curvature and stress values. Large scale studies are needed to further confirm our findings.