Relationship Between Onset-to-Door Time and Door-to-Thrombolysis Time A Pooled Analysis of 10 Dedicated Stroke Centers
Relationship Between Onset-to-Door Time and Door-to-Thrombolysis Time A Pooled Analysis of 10 Dedicated Stroke Centers
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DOI：
10.1161/strokeaha.113.000995
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发表时间：
2013-10-01
期刊：
影响因子：
8.3
通讯作者：
Tatlisumak, Turgut
中科院分区：
文献类型：
--
作者：
Strbian, Daniel;Michel, Patrik;Tatlisumak, Turgut
背景与目的从不同的注册中心报道了卒中溶栓患者从发病到上门时间（ODT）和上门到针时间（DNT）之间的负相关关系。我们在专门的中风中心分析了这种关系和DNT的其他决定因素。方法前瞻性收集来自10个中心的连续缺血性脑卒中患者的资料，这些患者在症状出现后4.5小时内接受静脉溶栓治疗（n=7106）。使用回归分析分析DNT作为人口统计学和院前变量的函数，并考虑随时间的变化。结果6348例已知治疗延误的患者中位DNT为42分钟，且逐年急剧下降(P
Background and Purpose Inverse relationship between onset-to-door time (ODT) and door-to-needle time (DNT) in stroke thrombolysis was reported from various registries. We analyzed this relationship and other determinants of DNT in dedicated stroke centers.Methods Prospectively collected data of consecutive ischemic stroke patients from 10 centers who received IV thrombolysis within 4.5 hours from symptom onset were merged (n=7106). DNT was analyzed as a function of demographic and prehospital variables using regression analyses, and change over time was considered.Results In 6348 eligible patients with known treatment delays, median DNT was 42 minutes and kept decreasing steeply every year (P