Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant.
Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant.
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DOI：
10.1038/s41467-022-28089-y
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发表时间：
2022-01-24
影响因子：
16.6
通讯作者：
Lu J
中科院分区：
文献类型：
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作者：
Li B;Deng A;Li K;Hu Y;Li Z;Shi Y;Xiong Q;Liu Z;Guo Q;Zou L;Zhang H;Zhang M;Ouyang F;Su J;Su W;Xu J;Lin H;Sun J;Peng J;Jiang H;Zhou P;Hu T;Luo M;Zhang Y;Zheng H;Xiao J;Liu T;Tan M;Che R;Zeng H;Zheng Z;Huang Y;Yu J;Yi L;Wu J;Chen J;Zhong H;Deng X;Kang M;Pybus OG;Hall M;Lythgoe KA;Li Y;Yuan J;He J;Lu J
SARS-CoV-2 Delta变种在全球范围内迅速传播。为了提供有关其病毒学特征的数据，我们在这里报告了中国大陆首次发生的Delta本地传播。所有167例感染都可以追溯到第一个指示病例。对被隔离个体进行每日连续PCR检测表明，Delta感染者首次呈PCR阳性时的病毒载量平均比2020年初中国第一波疫情期间的A/B系感染者高约1000倍，这表明Delta感染早期病毒复制可能更快，传染性更强。Delta变异体的估计传播瓶颈大小通常较窄，在29个供体-受体传播对中具有1-3个病毒体。然而，轻微iSNV的传播导致了疫情中确定的34种替换中的至少3种，突出了宿主内变异在快速传播期间对群体水平病毒多样性的贡献。SARS-CoV-2 Delta变种在全球范围内迅速传播。在这里，作者分析了Delta在中国的单一传播链，并发现证据表明，与早期大流行谱系相比，它在早期感染期间更具传染性和复制速度更快。
The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of Delta in mainland China. All 167 infections could be traced back to the first index case. Daily sequential PCR testing of quarantined individuals indicated that the viral loads of Delta infections, when they first become PCR-positive, were on average ~1000 times greater compared to lineage A/B infections during the first epidemic wave in China in early 2020, suggesting potentially faster viral replication and greater infectiousness of Delta during early infection. The estimated transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in 29 donor-recipient transmission pairs. However, the transmission of minor iSNVs resulted in at least 3 of the 34 substitutions that were identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread. The SARS-CoV-2 Delta variant has spread rapidly worldwide. Here, the authors characterise a single chain of transmission of Delta in China, and find evidence that it is more infectious and replicates faster during early infection compared to early pandemic lineages.