Acute ischemic stroke: Relationship of brain lesion location & functional outcome
Acute ischemic stroke: Relationship of brain lesion location & functional outcome
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DOI：
10.1080/09638280802627702
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发表时间：
2009-01-01
影响因子：
2.2
通讯作者：
Trebinjac, Suad Mustafa
中科院分区：
文献类型：
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作者：
Nazzal, Mahmoud Ezzat;Saadah, Mohammed Ahmed;Trebinjac, Suad Mustafa
目的。方法应用脑螺旋CT(SCT)和改良Barthel指数(MBI)对早期强化康复治疗的急性缺血性卒中患者进行脑梗塞部位与功能预后的相关性研究。观察性队列、评估者盲法和相关的前瞻性12周研究，包括111名急性缺血性中风患者，在2003年期间连续接受早期强化住院康复计划(每周5天，每天3-5小时)。头颅SCT对诊断和分层进行确认。在入院和出院时，脑部病变部位与运动能力和功能结果相关。统计分析表明，运动能力、功能结果和脑损伤部位之间存在显著的相关性。深梗死组、深梗死组和浅表大梗死组、浅表小梗死组和浅表大梗死组在这一频率顺序上表现出最一致的改善。正常脑SCT组无统计学意义(P=0.051)，而双侧脑梗死组无明显变化。组间和组内差异均有高度显著性(P<；0.05)。即刻非对比脑SCT可作为急性缺血性卒中患者最终功能结局的独立预测因子。它可能会为临床医生提供一个机会，向中风患者及其亲属提供现实的期望。
Purpose. To establish, using brain spiral computerised tomography (SCT) and modified Barthel index (MBI), whether the location of cerebral infarction could be correlated with functional outcome in acute ischemic stroke patients who undergo early intensive rehabilitation.Methods. Observational cohort, assessor blinded and correlational prospective 12-weeks study that included 111 acute ischemic stroke patients, admitted consecutively to an early intensive inpatient rehabilitation programme (5 days a week, 3-5 h a day) during 2003. Confirmation of diagnosis and stratification was done by brain SCT. Brain lesion locations were correlated to motor performance and functional outcome, on admission and discharge, using MBI.Results. Statistical analysis demonstrated a significant correlation between motor performance, functional outcome and brain lesion locations. The groups with deep, combined deep and large superficial, small superficial and large superficial infarcts showed the most consistent improvement in that order of frequency. Normal brain SCT group did not reach statistical significance (p = 0.051) while the bi-hemispheric infarcts group did not show any change. The inter and intra group differences were highly significant (p < 0.05).Conclusions. Immediate non-contrasted brain SCT may act as an independent predictor of final functional outcome in acute ischemic stroke. It may provide clinicians with an opportunity to offer realistic expectations to stroke patients and their relatives.