BLT Humanized Mice as Model to Study HIV Vaginal Transmission
BLT Humanized Mice as Model to Study HIV Vaginal Transmission
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DOI：
10.1093/infdis/jit318
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发表时间：
2013-11-15
影响因子：
6.4
通讯作者：
Luster, Andrew D.
中科院分区：
文献类型：
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作者：
Deruaz, Maud;Luster, Andrew D.
大多数人类免疫缺陷病毒1型（HIV-1）感染是通过性接触发生的，阴道传播占所有新感染的一半以上。对猴免疫缺陷病毒经阴道传播至非人灵长类动物（NHP）的研究表明，免疫细胞运输在感染建立以及病毒传播过程中发挥重要作用。然而，NHP模型不允许研究艾滋病毒的传播和传播。人源化小鼠模型的改进与强大的人类免疫细胞重建的女性生殖道，使这些小鼠易受阴道内HIV感染。因此，HIV阴道感染的人源化小鼠模型将允许研究HIV在体内传播和传播的机制。
The majority of human immunodeficiency virus type 1 (HIV-1) infections occur by sexual exposure, and vaginal transmission accounts for more than half of all newly acquired infections. Studies of vaginal transmission of simian immunodeficiency virus to nonhuman primates (NHPs) have suggested an important role for immune cell trafficking in the establishment of infection as well is in the process of viral dissemination. However, NHP models do not permit the study of HIV transmission and dissemination. The improvement of humanized mouse models with robust human immune cell reconstitution of the female genital tract renders these mice susceptible to intravaginal HIV infection. Thus humanized mouse models of HIV vaginal infection will allow the study of the mechanisms involved in HIV transmission and dissemination in vivo.