EVOLUTION OF TRANSCRIPTION NETWORKS IN RESPONSE TO TEMPORAL FLUCTUATIONS
EVOLUTION OF TRANSCRIPTION NETWORKS IN RESPONSE TO TEMPORAL FLUCTUATIONS
复制标题
转录网络响应时间波动的进化
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
S. Proulx
中科院分区：
文献类型：
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作者：
Kyoungmin Roh;F. Safaei;J. Hespanha;S. Proulx
生物体对环境变化的反应在生物和时间尺度上有很大的范围。这种表型可塑性可能涉及发育、行为、生理和遗传转变。已知可塑性反应的适应价值取决于生物体可获得的信息的性质以及可塑性反应的直接和间接成本。我们模拟了简单的基因调控网络的动态过程，因为它们响应于环境条件的时间波动。我们模拟了网络的进化，以确定当基因仅作为转录因子发挥作用时，它们本身没有直接功能，对网络的功能有利。当存在关于环境的完美信息并且不存在要提取的定时信息时，则将纯转录因子基因添加到网络中没有优势。相比之下，当存在可以提取的定时信息或仅存在关于环境的当前状态的间接信息时，则额外的转录因子基因改善进化的网络适应性。
Organisms respond to changes in their environment over a wide range of biological and temporal scales. Such phenotypic plasticity can involve developmental, behavioral, physiological, and genetic shifts. The adaptive value of a plastic response is known to depend on the nature of the information that is available to the organism as well as the direct and indirect costs of the plastic response. We modeled the dynamic process of simple gene regulatory networks as they responded to temporal fluctuations in environmental conditions. We simulated the evolution of networks to determine when genes that function solely as transcription factors, with no direct function of their own, are beneficial to the function of the network. When there is perfect information about the environment and there is no timing information to be extracted then there is no advantage to adding pure transcription factor genes to the network. In contrast, when there is either timing information that can be extracted or only indirect information about the current state of the environment then additional transcription factor genes improve the evolved network fitness.