Vaccination against Human Papilloma Virus (HPV): Epidemiological Evidence of HPV in Non-genital Cancers
Vaccination against Human Papilloma Virus (HPV): Epidemiological Evidence of HPV in Non-genital Cancers
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DOI：
10.1007/s12253-010-9288-0
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发表时间：
2011-03-01
影响因子：
2.8
通讯作者：
Spandidos, Demetrios A.
中科院分区：
文献类型：
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作者：
Mammas, Ioannis N.;Sourvinos, George;Spandidos, Demetrios A.
最近，人乳头瘤病毒（HPV）疫苗被纳入世界上几个国家的国家疫苗接种规划。人乳头瘤病毒与宫颈瘤变进展之间的既定联系为疫苗对宫颈癌的预期保护提供了证据。在过去的二十年中，一些研究也检查了HPV在非生殖器癌症中的可能参与，并提出HPV在食道癌、喉癌、口咽癌、肺癌、尿路上皮癌、乳腺癌和结肠癌中的存在。HPV可能与这些类型的癌症有关，因此有必要在男孩和女孩中引入疫苗。然而，HPV在这些类型的癌症发病机制中的作用尚未得到证实。此外，关于接种HPV疫苗在预防非生殖器癌症方面可能产生的影响的有争议的证据需要进一步评估。在这篇综述中，我们提出了现有的流行病学证据关于HPV检测非生殖器癌的概述。
Recently, the vaccine against human papillomavirus (HPV) was introduced in the national vaccination programmes of several countries worldwide. The established association between HPV and the progression of cervical neoplasia provides evidence of the expected protection of the vaccine against cervical cancer. During the last two decades several studies have also examined the possible involvement of HPV in non-genital cancers and have proposed the presence of HPV in oesophageal, laryngeal, oropharyngeal, lung, urothelial, breast and colon cancers. The possible involvement of HPV in these types of cancer would necessitate the introduction of the vaccine in both boys and girls. However, the role of HPV in the pathogenesis of these types of cancer has yet to be proven. Moreover, the controversial evidence of the possible impact of the vaccination against HPV in the prevention of non-genital cancers needs to be further evaluated. In this review, we present an overview of the existing epidemiological evidence regarding the detection of HPV in non-genital cancers.