Long-duration hippocampal sharp wave ripples improve memory
Long-duration hippocampal sharp wave ripples improve memory
复制标题
DOI：
10.1126/science.aax0758
复制
发表时间：
2019-06-14
期刊：
影响因子：
56.9
通讯作者：
Buzsaki, Gyorgy
中科院分区：
文献类型：
--
作者：
Fernandez-Ruiz, Antonio;Oliva, Azahara;Buzsaki, Gyorgy
海马区尖波纹波(SPW-Rs)被认为是记忆巩固和行动计划的机制。涟漪持续时间呈偏态分布，少数长持续时间事件。我们发现，在老鼠需要记忆的情况下，长时间的涟漪会增加。通过光遗传刺激延长自发产生的波纹，而不是随机诱导的波纹，增加了迷宫学习过程中的记忆。随机诱发纹波的神经元内容类似于短时间的自发纹波，包含的空间信息很少。光遗传延长的纹波的尖峰含量被正在进行的、自然启动的神经元序列所偏向。长时间的涟漪招募了代表迷宫任一臂的新神经元。长时间的海马区SPW-R重播大部分计划路线对记忆至关重要。
Hippocampal sharp wave ripples (SPW-Rs) have been hypothesized as a mechanism for memory consolidation and action planning. The duration of ripples shows a skewed distribution with a minority of long-duration events. We discovered that long-duration ripples are increased in situations demanding memory in rats. Prolongation of spontaneously occurring ripples by optogenetic stimulation, but not randomly induced ripples, increased memory during maze learning. The neuronal content of randomly induced ripples was similar to short-duration spontaneous ripples and contained little spatial information. The spike content of the optogenetically prolonged ripples was biased by the ongoing, naturally initiated neuronal sequences. Prolonged ripples recruited new neurons that represented either arm of the maze. Long-duration hippocampal SPW-Rs replaying large parts of planned routes are critical for memory.