Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate
Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate
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DOI：
10.1016/s0028-3932(02)00043-x
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发表时间：
2002-01-01
期刊：
影响因子：
2.6
通讯作者：
Andreasen, NC
中科院分区：
文献类型：
--
作者：
Nopoulos, P;Berg, S;Andreasen, NC
认知缺陷已经在非综合征性唇腭裂儿童中得到了很好的证明。然而，迄今为止还没有研究正式评估患有唇沟的成年人的认知能力。本研究旨在评估非综合征唇腭裂成年男性（n = 50）的神经心理功能与年龄和性别匹配的controls.Subjects唇腭裂被发现有显着较低的全面智商，操作智商和言语智商分数相比，其匹配的controls.Subjects。在控制了智商之后，患者在语言流畅性方面表现出特定的缺陷。由于面部的发育与大脑的发育高度相互依赖，因此理论上这些认知缺陷的病因是大脑发育异常的主要问题。(C)2002爱思唯尔科技有限公司版权所有。
Cognitive deficits have been well-documented in children with non-syndromic clefts of the lip and/or palate. However, no study to date has formally assessed cognition in adults with oral clefts. This study was designed to evaluate neuropsychological functioning in adult males with non-syndromic clefts of the lip and/or palate (n = 50) compared to age and sex-matched controls.Subjects with oral clefts were found to have significantly lower full scale IQ, performance IQ and verbal IQ scores compared to their matched controls. After controlling for IQ, patients showed specific deficits in verbal fluency.Adult males with oral clefts manifest a specific pattern of cognitive deficits. As the development of the face is highly interdependent with the development of the brain, it is theorized that the etiology of these cognitive deficits is a primary problem with abnormal brain development. (C) 2002 Elsevier Science Ltd. All rights reserved.