Effect of doxorubicin on heart mitochondrial enzymes in rats: a protective role for alpha-tocopherol.
Effect of doxorubicin on heart mitochondrial enzymes in rats: a protective role for alpha-tocopherol.
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阿霉素对大鼠心脏线粒体酶的影响：α-生育酚的保护作用。
DOI：
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发表时间：
1992
影响因子：
0.6
通讯作者：
C. Devi
中科院分区：
文献类型：
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作者：
A. Geetha;C. Devi
在给予或不给予α-生育酚的大鼠中研究了多柔比星对心脏线粒体酶的影响。给大鼠腹腔注射阿霉素2.5 mg/kg，每周一次，共8周。α-生育酚经口联合给药2个月（每日400 mg/kg体重）。阿霉素处理后TCA循环酶、NADH-脱氢酶、细胞色素C-氧化酶和Na+，K（+）-ATP酶活性降低。观察到蛋白酶活性显著降低，同时线粒体蛋白水平增加。线粒体过氧化脂质水平被认为是增加与巯基含量的减少。发现α-生育酚共同施用维持线粒体酶活性以及硫醇含量。参考α-生育酚的抗氧化性质的结果进行了讨论。
Effect of doxorubicin on heart mitochondrial enzymes was studied in rats with or without the administration of alpha-tocopherol. Rats were treated with doxorubicin 2.5 mg/kg, ip body wt once a week for 8 weeks. Alpha-tocopherol was co-administered orally for 2 months (400 mg/kg body wt daily). TCA cycle enzyme, NADH-dehydrogenase, cytochrome-C-oxidase and Na+,K(+)-ATPase activities were found to be decreased in doxorubicin treatment. A significant decrease in protease activity was observed with a concomitant increase in mitochondrial protein level. Mitochondrial lipid peroxide level was found to be increased with a decrease in thiol content. Alpha-tocopherol co-administration was found to maintain the mitochondrial enzyme activities as well as the thiol content. The results are discussed with reference to the antioxidant nature of alpha-tocopherol.