Impact of Information About Obesity Genomics on the Stigmatization of Overweight Individuals: An Experimental Study
Impact of Information About Obesity Genomics on the Stigmatization of Overweight Individuals: An Experimental Study
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DOI：
10.1038/oby.2012.144
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发表时间：
2012-12-01
期刊：
影响因子：
6.9
通讯作者：
Sanderson, Saskia C.
中科院分区：
文献类型：
--
作者：
Lippa, Natalie C.;Sanderson, Saskia C.
基因组技术的进步迅速使人们对基因变异在肥胖中所起的作用有了新的理解。增加公众传播有关遗传在肥胖中的作用的信息，可能会对肥胖个人的污名产生有益的、有害的或中性的影响。这项研究使用在线调查和实验设计来检验遗传和非遗传信息对自我感知的非超重个体中肥胖污名的影响。参与者(n=396)被随机分配阅读遗传性、非遗传性(环境)或基因-环境交互作用的肥胖原因信息。共有48%的参与者是女性；平均年龄为42.7岁(范围为18-86岁)；75%是白人；45.2%的家庭年收入低于40,000美元；平均BMI为23.4公斤/米(2)。采用肥胖恐惧量表-简式问卷(FPS-S)测量肥胖污名。在阅读了实验信息后，遗传和基因环境条件下的参与者比非遗传条件下的参与者更有可能相信基因会增加肥胖风险(P<；0.05)，但在肥胖污名上没有区别。白人和亚裔的肥胖污名高于拉美裔和非裔美国人(P=0.029)，并与低自尊有关(P=0.036)。肥胖污名与持有“细菌或病毒”(P=0.033)和“过度工作”(P=0.016)的原因信念负相关，与“饮食或饮食习惯”(P=0.001)和“缺乏锻炼”(P=0.004)的原因信念正相关。与自我感觉到的非超重个体中的非遗传信息相比，传播关于遗传在肥胖中的作用的简短信息对肥胖污名的影响可能既不是有益的，也不是有害的。
Advances in genomic technologies are rapidly leading to new understandings of the roles that genetic variations play in obesity. Increasing public dissemination of information regarding the role of genetics in obesity could have beneficial, harmful, or neutral effects on the stigmatization of obese individuals. This study used an online survey and experimental design to examine the impact of genetic versus non-genetic information on obesity stigma among self-perceived non-overweight individuals. Participants (n = 396) were randomly assigned to read either genetic, non-genetic (environment), or gene-environment interaction obesity causal information. A total of 48% of participants were female; mean age was 42.7 years (range = 18-86 years); 75% were white; 45.2% had an annual household income of less than $40,000; mean BMI was 23.4 kg/m(2). Obesity stigma was measured using the Fat Phobia Scale - short form (FPS-S). After reading the experimental information, participants in the genetic and gene-environment conditions were more likely to believe that genetics increase obesity risk than participants in the non-genetic condition (both P < 0.05), but did not differ on obesity stigma. Obesity stigma was higher among whites and Asians than Hispanics and African Americans (P = 0.029), and associated with low self-esteem (P = 0.036). Obesity stigma was also negatively associated with holding 'germ or virus' (P = 0.033) and 'overwork' (P = 0.016) causal beliefs about obesity, and positively associated with 'diet or eating habits' (P = 0.001) and 'lack of exercise' (P = 0.004) causal beliefs. Dissemination of brief information about the role of genetics in obesity may have neither a beneficial nor a harmful impact on obesity stigmatization compared with non-genetic information among self-perceived non-overweight individuals.