Effect of chronic psychosocial stress-induced by subordinate colony (CSC) housing on brain neuronal activity patterns in mice
Effect of chronic psychosocial stress-induced by subordinate colony (CSC) housing on brain neuronal activity patterns in mice
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附属群体（CSC）住房引起的慢性社会心理应激对小鼠脑神经元活动模式的影响
DOI：
10.1080/10253890802042082
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发表时间：
2009
期刊：
影响因子：
2.3
通讯作者：
S. Reber
中科院分区：
文献类型：
--
作者：
G. Singewald;N. K. Nguyen;I. Neumann;N. Singewald;S. Reber
慢性从属群体(CSC)安置是一种慢性心理社会应激的小鼠模型，与单独安置的对照(SHC)小鼠相比，该模型可引起应激相关参数的改变，包括体重增加减少和焦虑水平增加。应用免疫组织化学即刻早期基因(IEG)定位技术，研究CSC住房是否引起杏仁核、海马、隔区、中脑导水管周围灰质(PAG)和下丘脑室旁核(PVN)等边缘区域神经元激活模式的改变。与SHC小鼠相比，CSC小鼠在伏隔核外壳的基础ZIF-268表达增加，而在外侧隔区腹侧和中间亚区、细小细胞PVN和海马背CA3区，CSC小鼠对随后开放臂(OA)暴露的IEG反应减弱。相反，在CSC小鼠中，观察到OA暴露后，背内侧PAG的c-Fos反应增强。证实了先前在高架正迷宫上获得的发现，与SHC小鼠相比，CSC在OA暴露期间也观察到与焦虑相关的行为增强。为了探索适合CSC安置的控制条件，在行为学测试中加入了分组安置对照(GHC)小鼠。有趣的是，与SHC小鼠相比，GHC和CSC小鼠在OA暴露期间表现出显著较少的风险评估/探索行为，这表明集体收容本身对小鼠有压力，不足以控制CSC范式。总体而言，CSC住房是一种与行为相关的慢性心理社会应激源，导致对随后的新的、令人厌恶的挑战的敏感度提高。然而，与SHC相比，CSC诱导的焦虑相关行为的增加伴随着神经元激活的差异，这些神经元激活的特定脑区涉及情绪性和应激反应的处理。
Chronic subordinate colony (CSC) housing has been recently validated as a murine model of chronic psychosocial stress which induces alterations of stress-related parameters including decreased body-weight gain and an increased level of anxiety in comparison with single housed control (SHC) mice. By using immunohistochemical immediate early gene (IEG) mapping we investigated whether CSC housing causes alterations in neuronal activation patterns in limbic areas including the amygdala, hippocampus, septum and the periaqueductal gray (PAG) and hypothalamic paraventricular nucleus (PVN). While CSC housing increased basal Zif-268 expression in the nucleus accumbens shell compared to SHC, IEG responses to subsequent open arm (OA) exposure were attenuated in the ventral and intermediate sub-regions of the lateral septum, parvocellular PVN and the dorsal CA3 region of the hippocampus of CSC compared with SHC mice. In contrast, a potentiated c-Fos response in CSC mice was observed in the dorsomedial PAG after OA exposure. Confirming previous findings obtained on the elevated plus-maze, an enhanced anxiety-related behavior in CSC compared with SHC mice was also observed during OA exposure. In order to investigate the appropriate control conditions for CSC housing, group housed control (GHC) mice were additionally included in the behavioral testing. Interestingly, GHC as well as CSC mice showed significantly less risk assessment/exploratory behavior during OA exposure compared with SHC mice indicating that group housing itself is stressful for mice and not an adequate control for the CSC paradigm. Overall, CSC housing is an ethologically relevant chronic psychosocial stressor which results in an elevated sensitivity to a subsequent novel, aversive challenge. However, the CSC-induced increase in anxiety-related behavior was accompanied by differences in neuronal activation, compared with SHC, in defined sub-regions of brain areas known to be involved in the processing of emotionality and stress responses.
基于游泳应激诱导的 fos 样免疫反应的拮抗作用的抗抑郁药的功能分类。
DOI：
--
发表时间：
1996
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Duncan,GE;Knapp,DJ;Johnson,KB;Breese,GR
通讯作者：
Breese,GR
影响因子：
4.8
作者：
Ostrander, MM;Ulrich-Lai, YM;Herman, JP
通讯作者：
Herman, JP